Recent studies have documented an increased risk of therapy-related myelodysplastic syndrome or acute myelogenous leukemia (t-MDS/AML) after autologous bone marrow transplant (ABMT) for non-Hodgkin's lymphoma (NHL). To develop methods to identify patients at risk for this complication, we have investigated the predictive value of clonal bone marrow (BM) hematopoiesis for the development of t-MD...

Over the last decade, the zebrafish has cemented itself as a unique model system for providing new insights into the regulatory factors required for vertebrate hematopoiesis. In particular, the ease of genetic manipulation together with the transparency of embryos facilitating high resolution imaging has enabled the fate mapping of a host of blood cell lineages. Most notably, this has included ...

Introduction. Myelodysplastic syndromes represent clonal neoplastic disorders characterized by hematological dysplasia, ineffective hematopoiesis, cytopenia, and increased risk of transformation to acute myeloid leukemia. Material Methods. A literature review was conducted using the following bibliographic databases: Google Scholar, MEDLINE, Kobson. The recommendations for diagnosis, classifica...

The model organism Danio rerio, also known as the zebrafish, is an excellent system for studying the developmental process of hematopoiesis. It is an ideal model for in vivo imaging, and it is useful for large-scale genetic screens. These have led to the discovery of previously unknown players in hematopoiesis, as well as helped our understanding of hematopoietic development. In this review, we...

Primitive hematopoiesis occurs in the yolk sac blood islands during vertebrate embryogenesis, where abundant phosphatidylcholines (PC) are available as important nutrients for the developing embryo. However, whether these phospholipids also generate developmental cues to promote hematopoiesis is largely unknown. Here, we show that lysophosphatidic acid (LPA), a signaling molecule derived from P...

Major contributions to research in hematopoiesis in invertebrate animals have come from studies in the fruit fly, Drosophila melanogaster, and the freshwater crayfish, Pacifastacus leniusculus. These animals lack oxygen-carrying erythrocytes and blood cells of the lymphoid lineage, which participate in adaptive immune defense, thus making them suitable model animals to study the regulation of b...

СOVID-19 is a systemic disease with dysfunction of the immune system and damage to internal organs, including liver. The purpose study fnd out impact SARS-CoV-2 virus on liver, possibility its recovery after coronavirus infection. We examined 112 patients positive test for COVID-19. А clinical examination, biochemical blood tests, computed tomography chest, pulse oximetry, ultrasound examinatio...

Fetal liver hematopoiesis in mice disappears approximately 2 weeks after birth; however, under experimental acute anemia extramedullary hematopoiesis occurs in the livers of adult mice. The hematopoietic foci in the liver during extramedullary hematopoiesis contain erythroblasts and macrophages. In this study, the extent of involvement of macrophages in the development and involutional process ...