A 57-year-old woman with angioimmunoblastic lymphoma received allogenic hematopoietic stem cell transplantation (aHCT) after complete remission under 4th -line chemotherapy. One month aHCT, PET-scan showed progress of the lymphoma. Therefore, immunosuppressants (including mycophenolate mofetil and cyclosporine A) were reduced to enhance graft versus tumor reaction. An anti-infective prophylaxis...

introduction : in iran along with other countries, as transplant technology progresses and advances, the number of patients undergoing transplantation is rising steadily. in order to make stem-cell transplantation (sct) safer and more effective, psychological distress of patients must be taken in to account. patients are facing challenges pre- and post-transplantation. this study attempts to me...

background: thalassemia is probably the most common single gene disorder causing a major public health problem in the world. currently, allogenic hematopoietic stem cell transplantation (hsct) is the only curative therapy for thalassemia. one major limitation of hsct is the lack of hla-identical sibling donors, so attention has turned to finding phenotypically matched unrelated donors. patients...

Abstract A promising strategy to increase the numbers of hematopoietic stem cells (HSCs) for clinical applications, like cell transplantation, is offered by advanced in vitro culture systems. We developed artificial 3D bone marrow-like scaffolds made polydimethylsiloxane (PDMS) mimicking natural HSC niche . These PDMS combination with an optimized medium allow amplification high undifferentiate...

Hematopoietic stem cell transplantation is the curative option for patients with myelodysplastic syndrome; however, it requires a long post-transplantation follow-up. A 53-year-old woman with a diagnosis of myelodysplastic syndrome underwent related donor allogeneic hematopoietic stem cell transplantation in July 2006. Three months after transplantation, a comparative short tandem repeat analys...

Hematopoietic stem cell transplantation has revolutionized the treatment of hematologic malignancies, but infection, graft-versus-host disease and relapse are still important problems. Calcineurin inhibitors, T-cell depletion strategies, and immunomodulators have helped to prevent graft-versus-host disease, but have a negative impact on the graft-versus-leukemia effect. T cells and natural kill...

Hematopoietic stem cells (HSCs) are the best characterized adult stem cells and the only stem cell type in routine clinical use. The concept of stem cell transplantation laid the foundations for the development of novel cell therapies within, and even outside, the hematopoietic system. Here, we report on the history of hematopoietic cell transplantation (HCT) and of HSC isolation, we briefly su...

Peripheral blood stem cell transplantation (PBSCT) is the most common transplantation procedure performed in medicine. Its clinical introduction in 1986 replaced BM as a stem-cell source to approximately 100% in the autologous and to approximately 75% in the allogeneic transplantation setting. This historical overview provides a brief insight into the discovery of circulating hematopoietic stem...

introduction: accumulating evidences indicated that during increasing of the animals' age, the number and the functional properties of hematopoietic stem cells (hscs) become altered because of a gradual decrease in replication potential.  the efficient factors in this process are dna damaging, reduced telomerase activity, shortening of telomeres and oxidative stresses. for overcoming these fact...