Spinal cord injury (SCI) is a neurologic disorder that have a significant impact on quality of life, life expectancy, and economic burden. SCI leads to irreversible neuronal loss and ultimately leads to paralysis. Mesenchymal stem cells (MSCs) are a promising source for cellular therapy because they have possessed the capacity of self-renewal and differentiation to several distinct mesenchymal ...

methylprednisolone (mp) has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (sci). because of its controversial useful effects, the combination of mp and other pharmacological agents to enhance neuroprotective effects is desirable. magnesium sulfate (mgso4) has been shown to have neuroprotective and antihyperalgesic effects. in the present study, we soug...

NG2 belongs to the family of chondroitin sulfate proteoglycans that are upregulated after spinal cord injury (SCI) and are major inhibitory factors restricting the growth of fibers after SCI. Neutralization of NG2's inhibitory effect on axon growth by anti-NG2 monoclonal antibodies (NG2-Ab) has been reported. In addition, recent studies show that exogenous NG2 induces a block of axonal conducti...

Studies with omega-3 polyunsaturated fatty acids (PUFA) have shown that these compounds have therapeutic potential in several indications in neurology and psychiatry. Acute spinal cord injury (SCI) is an event with devastating consequences, and no satisfactory treatment is available at present. The pathogenetic mechanisms associated with SCI include excitotoxicity, increased oxidation and infla...

Background: Spinal cord injury (SCI) stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. The purpose of this study was to determine the anti-inflammatory effects of epigallocatechin gallate (EGCG) on traumatized spinal cord. Methods: Rats were randomly divided into four groups of 12 rats each as follow: sham-operated group, trauma group...

32 While walking in a straight path, changes in speed result mainly from adjustments in the 33 duration of the stance phase while the swing phase remains relatively invariant, a basic feature of 34 the spinal central pattern generator (CPG). To produce a broad range of locomotor behaviors, the 35 CPG has to integrate modulatory inputs from the brain and the periphery and alter these 36 swing/st...

The aim of present study was to examine whether systemically delivered glial cell-derived neurotrophic factor (GDNF) was beneficial in reversing the spinal cord injury (SCI) in a spinal cord compression model. Rats were divided into three major groups: (1) sham operation (laminectomy only); (2) laminectomy+SCI+normal saline (1 ml/kg, i.v.); (3) laminectomy+SCI+GDNF (50 ng/kg, i.v.). Spinal cord...

Background: Epidemic preventive management during the coronavirus disease 2019 (COVID-19) pandemic may have negatively impacted perioperative outcomes in patients with traumatic spinal cord injury (SCI). However, little is known about relationship between epidemic and delirium after SCI. Here, we clarified predictors of SCI surgery.