Maintenance hemodialysis patients display evidence of elevated interleukin-1 (IL-1) and tumor necrosis factor alpha release after stimulation either by contaminated dialysate, bioincompatible membrane material, or both. This release is followed by the stimulated secretion of a large number of other interleukins, particularly IL-6, the cytokine principally responsible for acute-phase protein syn...

BACKGROUND AND OBJECTIVES Although several studies have found that the burden of symptoms in patients who are on maintenance hemodialysis is substantial, little is known about renal providers' awareness of these symptoms. The aim of this study was to assess renal provider recognition of symptoms and their severity in hemodialysis patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The Dia...

The adverse effects of increased blood lead levels have been well discussed. Several antioxidant agents have been reported to offer protection from lead toxicity and to reduce blood lead levels (BLL). Given that erythropoietin (EPO) also has antioxidant properties, the aim of this cross-sectional study was to assess the role of EPO and other clinical variables on BLL in hemodialysis (HD) patien...

AIM Hyperkalemia increases the risk of sudden cardiac death (SCD) in hemodialysis patients. Our objective was to determine the association between administering low potassium dialysate to hyperkalemic hemodialysis patients and SCD. METHODS We conducted a retrospective cohort study with patients undergoing maintenance hemodialysis from May 1, 2006, through December 31, 2013. The dialysate comp...

OBJECTIVES The aim of this study was to assess safety and effectiveness of Whole Body Vibration exercise (WBV) to improve physical performance and parameters of inflammation in patients on maintenance hemodialysis (MHD). METHODS Prospective, open-label trial in n=14 patients on maintenance hemodialysis. Participants performed WBV twice weekly for 12 weeks before (n=8) or after (n=6) hemodialy...

OBJECTIVE To describe the causes, characteristics and factors associated with ascites in patients on maintenance hemodialysis. STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, from November 2007 to November 2014. METHODOLOGY All patients on maintenance hemodialysis and age > 16 year...

INTRODUCTION The relationship between smoking and mortality in patients on hemodialysis is controversial. Earlier studies showed that the insertion/deletion (I/D) polymorphism of the ACE gene might have an effect on mortality. The aim of this study was to test the impact of smoking on survival and whether this association was influenced by ACE gene I/D polymorphism in patients on maintenance he...

Objectives: L-carnitine has been used as therapy in hemodialysis patients for many years. When HCV was present, higher rates of patient mortality displayed. However, no study is concerned with the synergistic effect of L-carnitine and HCV. The purpose of this study was to investigate the effect of L-carnitine on the markers of DNA damage and oxidative stress in maintenance hemodialysis patients...

Hemodialysis affects biomarkers concentration in blood. The aim of this study is to evaluate the effects of hemodialysis on commonly used tumor markers. A total of 28 unselected patients (22 men and 6 women) with end-stage renal disease (ESRD), treated with maintenance hemodialysis, were enrolled in this study. GOT and tumor markers such as CA-153, CA-125, and CEA are measured. The mean age was...