background: although a variety of methods have been suggested to reduce stress, anxiety and pain intensity due to spinal needle skin puncture, their adverse effects restrict theirs widespread administration. in this study we evaluated the effects of oral tizanidine on the reduction of pain caused by spinal needle puncture and hemodynamic responses. methods : in this double blind randomized clin...

Adequate personalized numerical simulation of hemodynamic indices in coronary arteries requires accurate identification the key parameters. Elastic properties vessels produce a significant effect on accuracy simulations. Direct measurements elasticity are not available general clinic. Pulse wave velocity (AoPWV) aorta correlates with aortic and elasticity. In this work, we present neural networ...

Orthostatic hypotension in patients with cobalamin (Cbl) deficiency has been reported previously in isolated cases but we are not aware of detailed systematic studies of hemodynamic and autonomic nervous system function in patients with cobalamin deficiency. We investigated hemodynamic and autonomic responses to 60 degrees passive head up tilt (HUT) in 21 patients with vitamin B12 deficiency, 2...

Early detection and accurate estimation of aortic stenosis (AS) severity are the most important predictors of successful long-term outcomes in patients. Current clinical parameters used for evaluation of the AS severity have several limitations including flow dependency. Estimation of AS severity is specifically challenging in patients with low-flow and low transvalvular pressure gradient condi...

BACKGROUND The aim of the present work was to assess cerebral hemodynamic changes in a porcine model of E.coli induced fulminant sepsis. METHODS Nineteen healthy female Hungahib pigs, 10-12 weeks old, randomly assigned into two groups: Control (n = 9) or Septic Group (n = 10). In the Sepsis group Escherichia coli culture suspended in physiological saline was intravenously administrated in a c...

The paper presents the results of a comprehensive assessment central hemodynamic and microcirculation indices in skin upper lower limbs 6–7-year-old children. 14 girls 7 boys were examined using laser Doppler flowmetry methods (the LASMA-PF device, allowing simultaneous recording by four sensors) analysis heart rate variability ("Varicard"). parameters characterizing determined signs appearing ...

The expected response to fluid infusion is an increase of cardiac output (CO), and this response depends mostly on the current cardiac function of the patient. The importance of the prediction of fluid responsiveness (FR) is based on the fact that fluid loading in hemodynamic unstable patients may be hazardous and dangerous, e.g., by exposing them to the risk of developing pulmonary edema. The ...

This study aims to (i) demonstrate the efficacy of a new surgical planning framework for complex cardiovascular reconstructions, (ii) develop a computational fluid dynamics (CFD) coupled multi-dimensional shape optimization method to aid patient-specific coronary artery by-pass graft (CABG) design and, (iii) compare the hemodynamic efficiency of the sequential CABG, i.e., raising a daughter par...