or other substances in these presumably normal specimens. The Access PRL assay after PEG treatment may be suitable despite the CV of 14% because PEG treatment is frequently used to detect macroprolactin interference (6). It is possible that two samples with low recoveries contained macroprolactin. Our experience with this assay is that samples with PEG recovery values Ͻ60% contain high-molecula...

Hemoglobin (Hb) H disease is a moderate form of α- thalassemia resulting from various genetic defects. HbH disease is not necessarily a benign disorder as has been generally thought. We present hereby a 25- year-old Iranian pregnant woman whom referred to our hospital for blood transfusion. She exhibited the clinical and hematological manifestation of HbH disease. Her father carries a common α-...

Hemoglobin Aalborg is a moderately unstable hemoglobin variant with no affiliation to serious hematological abnormality or major clinical symptoms under normal circumstances. Our index person was a healthy woman of 58, not previously diagnosed with hemoglobinopathy Aalborg, who developed acute respiratory failure after a routine cholecystectomy. Initially she was suspected of idiopathic interst...

H EMOGLOBIN J was first reported in an American Negro family by Thorup et al.’ in 1956. Subsequently, it has been found in Indonesians,2’ East Indians,4’5 French-Canadians,6 Chinese,7 a Negro-Caucasian,5 and most recently in a family of Hawaiian-Chinese-Caucasian ancestry.’ The hemoglobin “Liberian I” described by Robinson et al.’” was formerly’ designated as hemoglobin J but recently has been ...

UNLABELLED Visual loss (acuity or field) secondary to ischemic optic neuropathy (ION) is a rare but devastating complication of cardiac surgery involving cardiopulmonary bypass (CPB). We determined clinical features and risk factors for ION by a retrospective time-matched, case-control study. ION was identified in 17 (0.06%) patients out of 27,915 patients who underwent CPB between January 1, 1...

BACKGROUND In persons with diabetes, chronic hyperglycemia (assessed by glycosylated hemoglobin level) is related to the development of microvascular disease; however, the relation of glycosylated hemoglobin to macrovascular disease is less clear. PURPOSE To conduct a meta-analysis of observational studies of the association between glycosylated hemoglobin and cardiovascular disease in diabet...

The etiologic agent of chancroid is Haemophilus ducreyi. To fulfill its obligate requirement for heme, H. ducreyi uses two TonB-dependent receptors: the hemoglobin receptor (HgbA) and a receptor for free heme (TdhA). Expression of HgbA is necessary for H. ducreyi to survive and initiate disease in a human model of chancroid. In this study, we used a swine model of H. ducreyi infection to demons...

OBJECTIVES In the Arabian Gulf region, hemoglobin (Hb) H disease usually results from homozygosity or compound heterozygosity involving the alpha2-globin gene polyadenylation (poly A) signal (AATAAA-->AATAAG) mutation (alpha(T)alpha). Here we document the clinical and hemato logical characteristics of children with Hb H disease being followed in Kuwait. SUBJECTS AND METHODS Twenty-four patien...

Studies of the ability of Plasmodium falciparum to grow in vitro in the red blood cells of subjects with certain beta-thalassemia syndromes are often difficult to interpret because of the known inhibitory effect of an elevated cellular content of human fetal hemoglobin (HbF). P falciparum therefore was cultured in vitro in the erythrocytes of subjects with hemoglobin H (HbH) disease and various...

Address for Correspondence: Dr. Şule Ünal, Hacettepe University, Division of Pediatric Hematology 06100 Ankara, Turkey Phone: +90 312 305 11 70 E-mail: [email protected] A three-year-old boy was referred to our hospital with the complaint of anemia resistant to iron treatment. Laboratory examination revealed hemoglobin (Hb): 8.7 g/dl, hematocrit (Hct): 30%, red blood cell (RBC): 5.5x109...