Malaria is still one of the largest medical threats to humans worldwide. Despite the global efforts to control it, many areas around the world remain malaria endemic, mainly confined to poor tropics and subtropics with huge global economic burdens [1]. In 2015, the World Health Organization (WHO) estimated about half of the world population is at risk of this disease, malaria deaths are so freq...

Low parasitemic condition in malaria remains a diagnostic challenge; as the available diagnostic methods failed to detect. Currently, hemozoin (Hz) pigment is gaining attention in the diagnosis of malaria. The major drawback is ease of detection of Hz in routine practice. A pilot study was conducted to evaluate the role of Hz pigment and to compare the performance of quantitative buffy coat ass...

Malaria parasites use hemoglobin (Hb) as a major nutrient source in the intraerythrocytic stage, during which heme is converted to hemozoin (Hz). The formation of Hz is essential for parasite survival, but to date, the underlying mechanisms of Hb degradation and Hz formation are poorly understood. We report the presence of a ∼200-kDa protein complex in the food vacuole that is required for Hb d...