conclusions based on the location of detected rccs in the structure of hbv proteins, it was found that these rccs may have a critical role in correct folding of hbv proteins and can be considered as drug targets. the results of this study provide new and deep perspectives about structure of hbv proteins for further researches and designing new drugs for treatment of hbv. results the pfam search...

conclusions fulminant hepatitis b is associated with distinct mutational patterns of hbv, underlining that genomic diversity of the virus is an important factor determining its pathogenicity. results the most commonly detected diversities affect regulatory motifs of hbv in the core and s region, indicating that these alterations may convert the virus to an aggressive strain. moreover, mutations...

hepatitis b virus (hbv) infection is the most common cause of end stage liver disease in iran and in golestan province. large-scale population-based prospective cohort studies with long term follow-up are the method of choice to accurately understand the natural course of hbv infection. to date, several studies of hbv epidemiology, natural history, progression to cirrhosis and association with ...

the study was conducted to determine the type, frequency and severity of gross, histopathologic changes, effect of route of infection and also, tissue tropism of serotype 793/b (4/91) infectious bronchitis virus. 20 day-old specific pathogen free chicks were inoculated intra-tracheally and intra-orally with 793/b serotype and lesions studied histopathologically at interval up to 10 days post-in...

hepatitis is the infections of a common cause disease among poly transfused patients. hepatitis c is slowed progression and inducing hcc. this study assessed hcc incidences, the role of iron and possible antitumor activity of chelators in 170 thalassemia patients using deferoxamine (dfo) therapy. they are diagnosed with hepatitis c due to positive pcr-rna. they are treated with ifn. the follow ...

background and aims: infectious bronchitis virus (ibv) causes an acute, highly contagious respiratory and kidney disease of chickens which results in significant economic losses in commercial broilers, layers and breeders. rapid identification of ibv serotypes involved in respiratory complex is a problem in the differential diagnosis. materials and methods: in this study, a single and multiplex...

results liver function tests in the healthy blood donors were within the normal range. the incidence rates of senv-d and senv-h in the 184 total blood donors were 10 (5.4%) (95% confidence interval (ci): 2.1% - 9.0%) and 32 (17.4%) cases (95% ci: 12.0% - 23.0%), respectively. senv-h/d co-infection occurred in 2 (1.1%) patients. the sera of 8/184 (4.3%) were positive for anti-hbc antibody but ne...

Background: Infections due to the hepatitis B (HBV) and hepatitis C (HCV) viruses constitute a global public health problem. Although screening of these infections remains a pivotal tool for timely detection and management of carriers, this preventive measure has been neglected in Africa. Objective: The current study determined the prevalence of hepatitis...

one of the most serious kinds of hepatitis is hepatitis b. this condition is more common than aids, and is 100 time more contagious. in iran the most common cause of acute and chronic hepatitis, liver cirrhosis, and also hepatocellar carcinoma in adults, is hepatitis b. more than two billion people are infected and more than 350 million of individuals are carriers of this virus in the entire wo...