Hepatocellular carcinoma is the third leading cause of cancer-related death in the world, and cirrhosis is the main cause of hepatocellular carcinoma and adversely affects surgical outcomes. Liver resection, liver transplantation, and local ablation are potentially curative therapies for early hepatocellular carcinoma (HCC). There exists an obvious histological variability of severity within ci...

Patients with hepatocellular carcinoma (HCC), the fifth most common cancer worldwide, display a highly variable clinical course, suggesting that HCC encompasses several biologically distinct subtypes. This heterogeneity has the potential to impede both treatment decisions and prognostic predictions for patients with HCC. One distinct, albeit rare, subtype of HCC is combined hepatocellular-chola...

Introduction Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Several novel therapeutic strategies have been developed to prolong survival patients with advanced HCC. However, decision-making biomarkers owing extensive heterogeneity Next-generation sequencing (NGS) generally used in treatment decisions help benefit from genome-directed targeting. Case presentation A 5...

Hepatocellular carcinoma (HCC) is the third cause of cancer-related mortality worldwide, accounting for more than 800,000 deaths annually. Surgical removal neoplasm remains most effective treatment option. Partial liver resection an adequate solution patients without cirrhosis or with well-compensated cirrhosis, orthotopic transplantation necessary in early stage HCC on background cirrhosis. Tu...

The purpose of this study was to explore the correlations arterial-phase enhanced CT characteristics hepatocellular carcinoma (HCC) with differentiation degree and expressions proliferating cell nuclear antigen (PCNA) phosphatase tensin homologue (PTEN). Seventy-nine HCC patients who underwent three-phase dynamic contrast-enhanced before surgery were selected observe characteristics. tissue eva...

Hepatocellular carcinoma (HCC) remains a major public health problem. MCM4, constitutive member of the minichromosomal maintenance protein family, has been reported to play vital role in cancer malignancy behavior. However, function MCM4 HCC largely unknown. The present study explored specific HCC. data from datasets including TCGA and GTEx showed that was overexpressed significantly associated...

Metastatic hepatocellular carcinoma (HCC) in the sinonasal region is rare. We report the case of a 45-year-old male hepatitis B carrier who had metastatic HCC 2 years after resection of the primary tumor. The patient died of terminal hepatic failure 6 weeks after the discovery of nasal septal metastasis. The clinical and histopathologic characteristics of the primary and metastatic hepatocellul...

The G protein-coupled receptor, class C, group 5, member A (GPRC5A) plays a key role in various diseases, but its effect on hepatocellular carcinoma (HCC) and the potential underlying mechanisms remains unclear. In present study, we explored of GPRC5A progression HCC further mechanism action. results revealed that expression was lower tissues cells. Overexpression suppressed proliferation epith...

Inguinal hernias are common diseases, but malignant lesions in groin rare; metastatic hepatocellular carcinoma (HCC) the hernia sac is extremely rare. We report a 72-year-old man who had advanced stage HCC with portal vein invasion and multiple lymphadenopathies. He presented painless palpable mass right groin. Computed tomography scan showed contrast-enhanced soft tissue (2.8 cm size) at herni...