Background: An attempt to establish the possible cause(s) of benign prostate hyperplasia (BPH) in fat feed albino rats treated with diclofenac (DCF)-potassium (K) was performed ascertain its likely translational relationship humans.Methods: Thirty-five male wistar 24 weeks old were divided into five groups 7 animals each used. Group 1; normal control (NC) injected subcutaneously vehicle (olive ...

Fungal infections caused by multidrug-resistant strains are considered one of the leading causes morbidity and mortality worldwide. Moreover, antifungal medications used in conventional treatment revealed poor therapeutic effectiveness possible side effects such as hepatotoxicity, nephrotoxicity, myelotoxicity. Therefore, current study was developed to determine green synthesized silver nanopar...

A study was conducted to evaluate the protective effect of aqueous seed extract of Carica papaya L. on gentamicin induced hepatotoxicity and nephrotoxicity in Wistar rats. A control group (Group I, n=12) was compared with rats administrated with 40 mg/kg gentamicin, once daily for 14 days (Groups II, III and IV, n=12 each). The effect of aqueous extract of Carica papaya L. at a dose level of 20...

The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines and animal models. To evaluate the hepatotoxicity and nephrotoxicity of A. cochinchinensis toward the livers and kidneys of ICR mice, alterations in related markers including body weigh...

Background & objectives: The present investigation was designed to evaluate the post-treatment properties of the hydroalcoholic fruit extract of cassia fistula (golden shower tree) in male Albino mice. Materials & Methods: Biomarkers and histological liver and kidney alterations, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), γ-glutamyl transferase...

BACKGROUND The aim of this study was to investigate the protective effects of L-glutamine (GLN) against liver and kidney injury caused by acute toxicity of deltamethrin (DLM). MATERIAL AND METHODS Thirty-two rats were indiscriminately separated into 4 groups with 8 rats each: control group (distilled water; 10 ml/kg, perorally [p.o.]), DLM group (35 mg/kg p.o. one dose.), GLN group (1.5 gr/kg...

BACKGROUND Aqueous extract of Morinda lucida benth leaf is consumed in Southern Nigeria in the treatment of malaria without any regard for its safety. AIM The aim of the study was to investigate the effects of ingestion of the ethanolic leaf extract of the plant on liver and kidney functions in Wistar albino rats. MATERIALS AND METHODS Acute oral toxicity test was performed to determine the...

To evaluate the hepatotoxicity and nephrotoxicity of Galla Rhois (GR) toward the liver and kidney of ICR mice, alterations in related markers including body weight, organ weight, urine composition, liver pathology and kidney pathology were analyzed after oral administration of 250, 500 and 1,000 mg/kg body weight/day of gallotannin-enriched extract of GR (GEGR) for 14 days. GEGR contained 68.7±...