Computer techniques were used to locate related segments of amino acid sequences in the thymidine kinases of vaccinia virus and of herpes simplex virus type 1 and in porcine adenylate kinase. As determined by a procedure that evaluates triply aligned sequences, the probability that the similarities among the segments described here arose by chance was no greater than 0.001. Because the sequence...

The role of cell-mediated protection to herpes simplex infection was studied in vivo and in vitro. Sensitized spleen cells, obtained from syngeneic mice immunized with herpes simplex virus, protected recipient mice against lethal chal lenge with herpes simplex virus. Survival was signifivantly greater in challenged mice that received washed spleen cells from donor animals immunized with herpes ...

High-resolution transcription mapping localized a spliced 2.7-kilobase herpes simplex virus type 1 mRNA. The 4-kilobase intron of this transcript encodes a nested set of transcripts on the opposite DNA strand. The nucleotide sequence of the DNA encoding the left-hand and right-hand exons of the spliced transcript was determined, and the salient features are presented here. Of major interest is ...

herpetic keratitis which is resulted from herpes simplex virus type i, is considered the most common cause of corneal blindness that needs being diagnosed and treated in order to prevent irreversible eye effects. the best method to diagnose it is molecular method which has high sensitivity and exclusivity. the current study was done on 25 eye samples collected from patients referred to the feyz...

Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV-1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV-1 strains in the brain and eye of 2 patients with acute retinal necrosis...

The effect of acyclovir on DNA synthesized in cells infected with herpes simplex virus type 1 was examined. DNA that was synthesized in infected cells in the presence of acyclovir during a short pulse with [3H]thymidine remained near the top of an alkaline sucrose gradient after centrifugation. The sedimentation characteristics of labeled DNA were not changed after chasing in isotope-free mediu...

OBJECTIVE To determine the prevalence of herpes viruses in the semen of an asymptomatic male cohort with and without infertility problems and its association with altered semen parameters. DESIGN A prospective randomized study. SETTING Medical school and IVF clinic. PATIENT(S) One hundred seventy-two male patients undergoing routine semen analysis: 80 with normal semen parameters (control...

It was demonstrated that newborn mice, surviving an infection with attenuated herpes simplex virus, become resistant to challenge with a pathogenic strain of herpes simplex virus. This resistance did not seem to be mediated by antibody.

childhood. Ambulatory Child Health. 2000;6:59-66. 4. Kalman CM, Laskin OL. Herpes zoster and zosteriform herpes simplex virus infections in immunocompetent adults. Am J Medic. 1986;81:775-8. 5. Nikkels AF, Nikkels-Tassoudji N, Piérard GE. Revisiting childhood herpes zoster. pediatr dermatol. 2004; 21:18-23. 6. Kakourou T, Theodoridou M, Mostrou G, Syriopoulou V, Papadogeorgaki H, Constantopoulu...

Herpes B-virus,cercopithecine herpesvirus 1;herpesvirus simian endemic in Asian macaques is related to herpes simplex(HSV) type 1 in humans; infection with herpes B-virus in humans can result in fatal encephalitis and neurologic impairment. Human infections have been by bites, scratches, and percutaneous inoculation. HerpesB-virus infection causes minimal morbidity in macaques. Inhumans herpes ...