Idoxuridine (5-iodo-2'-deoxyuridine) is a thymidine analogue which interferes with deoxyribonucleic acid (DNA) metabolism and inhibits herpes simplex virus multiplication. Its systemic use is limited by toxicity. Calabresi (1965) has recommended that it be used only for severe infections with DNA-containing viruses, or for malignant disease. We report a newborn infant with severe herpes simplex...

Kaposi’s varicelliform eruption (KVE) or eczema herpeticum is a disseminated viral infection superimposed on pre-existing dermatosis. It is frequently caused by Herpes simplex and certain other viruses. It may result on life-threatening viraemia with multiorgan involvement and secondary infections. We report a 34-year old female patient with KVE which is caused by herpes virus developed on irri...

A hallmark of the herpes family of viruses is their ability to cause recurrent disease. Upon primary infection, Herpes Simplex virus (HSV) establishes a latent infection in sensory neurons that persists for the life of the individual. Reactivation of these latent viral genomes with virion formation is the source of virus for most HSV recurrent disease. This review details recent exciting findin...

BACKGROUND The potential for faster detection of human herpes viruses using PCR compared to other methods is undisputed. However, because of fear of contamination, the clinical implication of nucleic amplification methods in routine laboratories is not widespread. Herpes viruses cause a wide spectrum of diseases and can cause morbidity and mortality in immune-compromised patients. Using real-ti...

BACKGROUND Infections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population. METHODS This study was performed in TRAILS, a large prospective general po...