PURPOSE Insulin-like growth factors (IGFs) are potent mitogens for breast cancer cells in vitro, and elevated IGF-I serum levels are a risk factor for breast malignancies. This study evaluated IGF-I and IGF-II serum levels in healthy women and in patients with benign and malignant breast lesions and correlated them with tumor size. EXPERIMENTAL DESIGN Serum levels of the total and unbound fra...

The aim of the present study was to compare the application value of the 3D stereo wire localization technique guided by a full digital breast X-ray machine, and general location technique in the resection of breast non-palpable lesions. A retrospective analysis of the clinical data of 80 patients with abnormal findings for non-palpable breast molybdenum target X-ray was conducted between June,...

Receptor Activator of NF-kappa B (RANK) pathway controls mammary gland development in mice but its role in mammary stem cell fate remains undefined. We show that constitutive RANK signaling expands luminal and basal mammary compartments including mammary stem and luminal progenitor cell pools and interferes with the generation of CD61+ and Sca1+ luminal cells and Elf5 expression. Impaired mamma...

The purpose of this study is to investigate whether an adjacent vessel sign (AVS) observed on the maximum intensity projections (MIPs) from the subtracted images can help distinguish between malignant and benign breast lesions and to test whether the combination of breast imaging reporting and data system (BI-RADS) category and AVS can increase the specificity and diagnostic accuracy of breast ...

R. Sinkus, K. Siegmann, T. Xydeas, M. Tanter, M. Fink Laboratoire Ondes et Acoustique, ESPCI, Paris, France, Universitätsklinikum Tübingen, Tübingen, Germany Synopsis 3D steady-state MR-Elastography is utilized to assess the transverse isotropic properties of benign and malignant breast lesions. Both shear moduli as well as the local fibre-orientation are reconstructed. Attenuation effects are ...

methods in this research, we utilized the chaos theory and fractal analysis in the interpretation of breast tumors on dce-mri. this cross-sectional study was done at pardisnoor imaging center during years 2015 and 2016 in iran. our sample size was 18 mass lesions, which were randomly selected among patients with birad 3 and birad 4 classification by the expert radiologist. the analysis was perf...

AIMS To analyse the expression of proteins involved in DNA double strand break detection and repair in the luminal and myoepithelial compartments of benign breast lesions and malignant breast tumours with myoepithelial differentiation. METHODS Expression of the ataxia telangiectasia (ATM) and p53 proteins was immunohistochemically evaluated in 18 benign and malignant myoepithelial tumours of ...

PURPOSE The aim of this study is to evaluate the clinical utility of automated breast volume scanner (ABVS) for detecting and diagnosing the breast lesions. METHODS From December 2010 to January 2012, bilateral whole breast examinations were performed with ABVS for 139 women. Based on the Breast Imaging Reporting and Data System (BI-RADS) categories, the breast lesions were evaluated on coron...

BACKGROUND The main goal of this study was to compare contrast-enhanced spectral mammography (CESM) and breast magnetic resonance imaging (MRI) with histopathological results and to compare the sensitivity, accuracy, and positive and negative predictive values for both imaging modalities. MATERIAL/METHODS After ethics approval, CESM and MRI examinations were performed in 102 patients who had ...

INTRODUCTION Papillary breast lesions are rare and constitute less than 10% of benign breast lesions and less than 1% of breast carcinomas. OBJECTIVE To analyse the clinical presentation, preoperative evaluation, and surgical and anatomopathological characteristics of the patients operated on for papillary breast lesions. MATERIAL AND METHODS Retrospective descriptive and analytical study. ...