Heterogeneity exists on a data set when samples from different classes are merged into the data set. Finite mixture models can be used to represent a survival time distribution on heterogeneous patient group by the proportions of each class and by the survival time distribution within each class as well. The heterogeneous data set cannot be explicitly decomposed to homogeneous subgroups unless ...

The active-site serine of the extracellular beta-lactamases of Streptomyces cacaoi and Streptomyces albus G has been labelled with beta-iodopenicillanate. The determination of the sequence of the labelled peptides obtained after trypsin digestion of the denatured proteins indicate both enzymes to be class A beta-lactamases. Surprisingly the two Streptomyces enzymes do not appear to be especiall...

bis-(l-tyrosinato)copper(ii) was reacted with 3-(chloropropyl)-trimethoxysilane functionalized silica that has infused magnetite to yield a magnetically separable catalyst in which the copper carboxylate is covalently linked to the silica matrix through the silane linkage. the immobilized catalyst has been characterized by spectroscopic studies (such as ft-ir, epr, magnetic measurement, sem) an...

background: the heterogeneous composition of the human body presents numerous tissue types and cavities with widely differing radiologic properties. the aim of the present work was to develop a low cost homogeneous and heterogeneous phantom and the absorbed dose were measured by ionization chamber for different radiotherapy treatment techniques and compared with treatment planning system absorb...

fe3o4 magnetic nanoparticles were synthesized by co-precipitation of fe2+ and fe3+ in aqueous naoh. then silica was coated on the obtained nanoparticles and the whole composite was functionalized with chlorosulfonic acid in ch2cl2. the obtained nanocomposite (fe3o4@sio2-so3h) was characterized by ft-ir, vsm and xrd techniques and was used as an efficient catalyst in condensation reaction of ind...

background: acinetobacter baumannii is an important opportunistic pathogen which causes complications in hospitalized patients, especially those in icu. the aim of this study was to determine the frequency of class 1 and 2 integrons in multi-drug resistance a. baumannii and to investigate the association between the presence of integrons and antibiotic resistance patterns. methods: a total of 4...

Activation-induced cytidine deaminase (AID) is essential for antibody class switch recombination (CSR) and somatic hypermutation (SHM). AID originally was postulated to function as an RNA-editing enzyme, based on its strong homology with apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 1 (APOBEC1), the enzyme that edits apolipoprotein B-100 mRNA in the presence of the APOBEC cofactor...

We employed a phage display system to search for proteins that interact with transportin 1 (TRN1), the import receptor for shuttling hnRNP proteins with an M9 nuclear localization sequence (NLS), and identified a short region within the N-terminus of the nucleoporin Nup153 which binds TRN1. Nup153 is located at the nucleoplasmic face of the nuclear pore complex (NPC), in the distal basket struc...