Protofibrils are transient structures observed during in vitro formation of mature amyloid fibrils and have been implicated as the toxic species responsible for cell dysfunction and neuronal loss in Alzheimer’s disease (AD) and other protein aggregation diseases. To better understand the roles of protofibrils in amyloid assembly and Alzheimer’s disease, we characterized secondary structural fea...

Open AccessCCS ChemistryRESEARCH ARTICLE1 May 2021An Unconventional trans-exo-Selective Cyclization of Alkyne-Tethered Cyclohexadienones Initiated by Rhodium(III)-Catalyzed C–H Activation via Insertion Relay Yun-Xuan Tan†, Xing-Yu Liu†, Shuo-Qing Zhang†, Pei-Pei Xie, Xin Wang, Kai-Rui Feng, Shao-Qian Yang, Zhi-Tao He, Hong, Ping Tian and Guo-Qiang Lin Tan† The Research Center Chiral Drugs, Inno...

Magnesium-based next-generation batteries are of great interest since magnesium is not only very abundant, which allows economic and sustainable applications, but also less prone to dendrite formation than many other metals. Together with the bivalency cations resulting possibility safely use a metal anode enables high specific capacities. However, for successful commercialization there still s...

The formation of alcohols and carbonyl derivatives via oxidation of the corresponding Csp–H bonds is crucial to the chemical community. Historically chemists have relied for these transformations on the use of organic or inorganic oxidants, which are often toxic and produce stoichiometric amounts of harmful waste. As we strive for a more sustainable fine chemicals synthesis, for which typically...

•Access to a wide range of linear alcohols and arylated alkanes•Compatible with aliphatic electronically deactivated epoxides•No pre-activation required for primary alcohols•Hexafluoroisopropanol is key the reactivity Substitution reactions are common way couple two molecular fragments at sp3-hybridized carbon atom. The one or both coupling partners typically required, which adds additional che...

Open AccessCCS ChemistryRESEARCH ARTICLE1 Aug 2021Electrochemical Ring Expansion to Synthesize Medium-Sized Lactams Through C–C Bond Cleavage Kun Liu†, Chunlan Song†, Xu Jiang, Xin Dong, Yuqi Deng, Wenxu Song, Yanpei Yang and Aiwen Lei Liu† College of Chemistry Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, 430072 †K. Liu C. Song contributed equally this work.Google...

Six strains of lecithinase-lipase-negative Clostridia, isolated from human feces, were capable of oxidizing chenodeoxycholic acid to 3a-hydroxy-7-keto-5P-cholanoic acid and of epimerizing it to ursodeoxycholic acid. The identity of the reaction products was confirmed by coniparing their mass spectra, obtained by combined gas-liquid chromatography-mass spectrometry, with those of authentic refer...

2009 WILEY-VCH Verlag Gm The dragline silk of certain spiders has excellent tensile properties that are maintained over a remarkable temperature range. Although the commercial Mulberry Silkworm (Bombyx mori) silk is considerably weaker and less tough than the best spider dragline silks, fibers with comprehensive mechanical properties approaching that of spiders can be obtained by force-reeling ...

The Division de Chimie Organique (DCO) of the Société Chimique France (SCF) and European Journal Organic Chemistry are coming together for second consecutive year to celebrate recipients 2021 DCO Awards. A close connection between a chemical society its journals is an essential component their respective successes, as it ensures mutual promotion. We therefore delighted continue collaboration, s...