Increasing evidence suggests that hypercholesterolemia during pregnancy initiates pathogenic events in the fetus leading to increased risk of cardiovascular disease in the adult offspring. In this study we examined in mice whether pharmacological intervention using statins in late pregnancy could alleviate the detrimental effects of a high-fat, high-cholesterol (45% fat) maternal diet on the he...

effects of partial docking on feedlot performance and body fat characteristics were studied in a fat-tailed sheep breed. thirty-eight male lambs with an average weight of 4.44 ± 0.48 were randomly divided into two groups. the lambs in one group were partially docked at 3-4 h after birth, using rubber rings, and the lambs in another group remained intact (control). after weaning, 20 male lambs f...

Conversion of tryptophan -to niacin in male weanling albino rats, fed high fat and high fat-high protein, was studied. High fat diet suppressed niacin biosynthesis from administered trypto phan. High protein along with high fat was found to overcome the deleterious effect of high fat on the conversion of tryptophan to niacin. Prolonged feeding of high fat decreased urinary , blood and tissue le...

BACKGROUND Pericardial and intrathoracic fat depots may represent novel risk factors for obesity-related cardiovascular disease. We sought to determine the prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat deposits. METHODS AND RESULTS Participants from the Framingham Heart Study (n=3312; mean age, 52 years; 48% women) underwent multidetector CT im...