Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered fr...

Although the mortality associated with breast cancer has decreased recently, it remains a major health problem. New technologies allow oncologists to study genetic risk factors and models for preneoplastic disease, with the ultimate aim of applying new findings to the prevention of breast cancer. Currently, breast cancer risk-reduction options for women at high risk include screening, chemoprev...

background: recent epidemiological studies demonstrate that obesity is associated with an increased risk for breast cancer in women. increased estrogen levels are suggested as one possible explanation, but this does not fully explain the relationship between obesity and breast cancer. one alternative explanation is secretion by adipocytes of metabolites, hormones and cytokines, collectively kno...

Backgrounds and Aims: One member of the cytochrome P450 family, CYP1A1, is one of the genes involved in the metabolism of carcinogens and estrogen, which has been identified to be associated with breast cancer, as well. Considering the known effect of estrogen in different signaling pathways, disorders in these pathways will affect the risk of breast cancer. In this study, we evaluated the rela...

1.1 Breast cancer and risk factors Breast cancer is the most common female cancer, the second most common cause of cancer death in women, and the main cause of death in women ages 40 to 59 (1). It has been reported that mortality rate from breast cancer has been significantly greater in women whose cancer was first diagnosed during pregnancy compared with those who had never been pregnant (2). ...

This study explored the associations between common PSCA single-nucleotide polymorphisms (rs2294008, rs2978974, and rs2976392) and breast cancer among 560 breast cancer cases and 583 controls (Chinese Han women). We found rs2294008 was significantly associated with a high risk of breast cancer (homozygote model, odds ratio [OR]: 1.67, 95% confidence interval [CI]: 1.06-2.59; recessive, OR: 1.64...

OBJECTIVE To characterise the current usage of chemoprevention agents among hospitalised women who are at higher risk for breast cancer. STUDY DESIGN A cross-sectional study. SETTING Academic hospital at Baltimore. PARTICIPANTS A bedside survey of 250 women aged 50-75 years was conducted who were cancer-free at the time of study enrolment and hospitalised to a general medicine service. Re...

Introduction: The etiology of male breast cancer is unclear, but hormonal levels may play a role in development of this disease. It seems that the risk of male breast cancer related to increased lifelong exposure to estrogen or reduced androgen. The aim of this study was to investigate the expression of the steroid hormone receptors including estrogen receptor (ER) and progesterone receptor (PR...