Chromosome aberrations are large-scale illegitimate rearrangements of the genome. They are indicative of DNA damage and informative about damage processing pathways. Despite extensive investigations over many years, the mechanisms underlying aberration formation remain controversial. New experimental assays such as multiplex fluorescent in situ hybridyzation (mFISH) allow combinatorial "paintin...

AIM To study the distribution of ocular higher-order aberrations(HOAs) and mesopic pupil size in individuals screened for refractive surgery. METHODS Ocular HOAs and mesopic pupil size were studied in 2 458 eyes of 1 240 patients with myopia, myopic astigmatism and compound myopic astigmatism and 215 eyes of 110 patients with hyperopia, hyperopic astigmatism and compound hyperopic astigmatism...

PURPOSE We investigated effects of pupil shifts, occurring with changes in luminance and accommodation stimuli, on refraction components and higher-order aberrations. METHODS Participants were young and older groups (n = 20; 22 ± 2 years; age range, 18-25 years; and n = 19, 49 ± 4 years, 45-58 years, respectively). Aberrations/refractions at 4- and 3-mm diameters were compared between centere...

We report the first experimental demonstration of even-order aberration cancellation in quantum interferometry. The effect is a spatial counterpart of the spectral group velocity dispersion cancellation, which is associated with spectral entanglement. It is manifested in temporal interferometry by virtue of the multiparameter spatial-spectral entanglement. Spatially entangled photons, generated...

PURPOSE To study the effects of ocular lubricants on higher order aberrations in normal and self-diagnosed dry eyes. METHODS Unpreserved hypromellose drops, Tears Again™ liposome spray and a combination of both were administered to the right eye of 24 normal and 24 dry eye subjects following classification according to a 5 point questionnaire. Total ocular higher order aberrations, coma, sphe...

PURPOSE The aim of this analysis was to determine the total ocular wavefront aberration values of a large phakic population of physiologically normal, ametropic eyes, gathered under the same clinical protocol using the same diagnostic wavefront sensor. MATERIALS AND METHODS Studies were conducted at multiple sites in Asia, North America, Europe, and Australia. A Bausch + Lomb Zywave II Wavefr...

Fold functions are a general mechanism for computing over recursive data structures. First-order folds compute results bottom-up. With higher-order folds, computations that inherit attributes from above can also be expressed. In this paper, we explore folds over a form of recursive higher-order function, called hyperfunctions, and show that hyperfunctions allow fold computations to coroutine ac...

We analyze theoretically, by means of both computer simulations and laboratory experiments, the limitations of correcting aberrations with ideal customized contact lenses. Four experiments are presented: In the first one, we have analyzed the limitations of a static correction on the dynamic wavefront. In the second one, we studied the rotations of a contact lens on the eye using an optical met...

The scalar version of the pathway model of Mathai (2005) is shown to be associated with a large number of probability models used in physics. Different families of densities are listed here, which are all connected through the pathway parameter α, generating a distributional pathway. The idea is to switch from one functional form to another through this parameter and it is shown that one can pr...