Advanced Glycation End Products (AGEs) are the final products of non-enzymatic protein glycation that results in loss of protein structure and function. We have previously shown that in E. coli AGEs are continually formed as high-molecular weight protein complexes. Moreover, we showed that AGEs are removed from the cells by an active, ATP-dependent secretion and that these secreted molecules ha...

The gradual development of SYSTEMS of typed symbols for describing chemical structures and substrunures (radicals) is traced from its beginning in 1787. Such symbols are emphasized because *computers are symbol processors par excellence." Computers are the central tools of the Information Age, but future trends in the management of chemical structure information are likely to reflect deeply roo...

Cardiovascular disease (CVD) is the leading cause of death and disability in the United States and in most industrialized nations. Major breakthroughs to modern day cardiovascular/lipid research have been attributed to the findings of the Framingham Heart Study and Gofman and colleagues who made associations between lipoprotein levels (LDL, VLDL and HDL) and CVD. Unfortunately, half of all CVD ...