A physiologically based pharmacokinetic (PBPK) model for isopropanol (IPA) and its major metabolite, acetone, is described. The structure of the parent chemical model, which can be used for either IPA or acetone by choosing the appropriate chemical-specific parameters, is similar to previously published models of volatile organic chemicals such as styrene. However, in order to properly simulate...

PURPOSE This study compared the dentin collagen cross-linking potential of carbodiimide (EDC) prepared in three most commonly used solvents in dental adhesive systems: water, ethanol, and acetone. MATERIALS AND METHODS Thirty-eight extracted caries-free human permanent molars were used in this study. Demineralized dentin beams were prepared and cross linked by 0.3 M EDC in water, acetone, or ...

Inasmuch as the accumulation of acetone bodies in the blood of a diabetic animal may exert a toxic influence, the study of acetone metabolism has been the subject of numerous investigations. The early observations made on surviving organs indicated that the perfusion of the liver with the amino acids, leucine, phenylalanine, or tyrosine caused an increased acetone content of the perfusate (Embd...

Removal of acetone and methyl isopropyl ketone (MIPK) in a composite bead biofilter was investigated. Both microbial growth rate kg and biochemical reaction rate kd would be inhibited at higher inlet concentration. For the microbial growth process, the kg value of MIPK was greater than that of acetone and the inhibitive effect for MIPK was more sensitive than that for acetone in the average inl...

Acetone is activated by aerobic and nitrate-reducing bacteria via an ATP-dependent carboxylation reaction to form acetoacetate as the first reaction product. In the activation of acetone by sulfate-reducing bacteria, acetoacetate has not been found to be an intermediate. Here, we present evidence of a carbonylation reaction as the initial step in the activation of acetone by the strictly anaero...

Recent determinations of the temperature dependence of acetone fluorescence have permitted the application of acetone planar laser-induced fluorescence imaging, which was already popular for mapping concentration, to the measurement of temperature. With a view toward developing temperature-imaging diagnostics, we present atmospheric-pressure fluorescence and absorption results acquired with exc...

This study investigates the fabrication and characterization of an acetone microsensor with a ring oscillator circuit using the commercial 0.18 μm complementary metal oxide semiconductor (CMOS) process. The acetone microsensor contains a sensitive material, interdigitated electrodes and a polysilicon heater. The sensitive material is α-Fe2O3 synthesized by the hydrothermal method. The sensor re...

Urinary amino-acetone concentrations were determined in a group of 51 persons with industrial exposure to lead and the findings compared with those obtained from a control group of 27 persons having no exposure to lead.A good correlation was found between delta-aminolaevulinic acid and amino-acetone excretion in the control group but this correlation was not so well defined in the lead-exposed ...

In heart failure patients, exhaled acetone concentration, a noninvasive biomarker, is increased according to heart failure severity. Moreover, exhaled acetone concentration is also known to be affected by diabetes mellitus. However, there have been no reports on exhaled acetone concentration in heart failure patients with diabetes mellitus. A 77-year old man was admitted to our hospital with ac...