Bendamustine (Treanda, Ribomustin) was recently approved by the US Food and Drug Administration (FDA) for treatment of patients with rituximab refractory indolent lymphoma and is expected to turn into a frontline therapy option for indolent lymphoma. This compound with amphoteric properties was designed in the former Germany Democratic Republic in 1960s and re-discovered in 1990s with multiple ...

Primary bone lymphoma (PBL) is a relatively uncommon entity. However, involvement of the cranial vault is an unusual manifestation of aggressive non-Hodgkin's lymphoma. We report the case of a 42-year old immunocompetent woman who presented with an enlarging mass involving the right parietal bone. Magnetic resonance imaging (MRI) of the brain revealed an expansive tumor that affects the right p...

T cells engineered to express chimeric antigen receptors (CARs) combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) signaling domain for triggering cell activation are being used for immunotherapeutic targeting of tumor cells in a non-HLA restricted manner. In this study we transduced T cells with a CD19-CAR construct containing a truncated CD34 gene (tCD34) marker...

Over the past decade, novel pathogens causing infections in patients have been identified. Chryseobacterium is one such emerging pathogen that frequently reported hospitalized patients. Case reports of bloodstream infections, and pneumonia due to spp cancer from different parts world are drawing attention clinical community this bacterium as an threat with malignancies. Besides its propensity c...

Targeted alpha therapy (TAT) is an emerging option for local and systemic cancer treatment. Preclinical research and clinical trials show that alpha-emitting radionuclides can kill targeted cancer cells while sparing normal cells, thus reducing toxicity. (223)RaCl2 (Xofigo(®)) is the first alpha emitting radioisotope to gain registration in the US for palliative therapy of prostate cancer bone ...

INTRODUCTION There are no population based cancer registries in Pakistan except for Karachi Cancer Registry (KCR). No data from Punjab is available in the last decade. We decided to conduct a data base analysis to see the frequencies of different cancers in Punjab. PATIENTS AND METHODS A retrospective analysis of 5100 patients presenting to Jinnah Hospital between January 1997 to December 200...

Abstract. To understand global soil organic matter (SOM) chemistry and its dynamics, we need tools to efficiently quantify SOM properties, for example, prediction models using mid-infrared spectra. However, the advantages of such rely on their validity accuracy. Recently, Hodgkins et al. (2018) developed quantitatively predict peat holocellulose Klason lignin contents, two indicators stability ...