Gap junctions (GJs) made of connexin-43 (Cx43) are necessary for the conduction electrical impulses in heart. Modulation Cx43 GJ activity may be beneficial treatment cardiac arrhythmias and other dysfunctions. The search novel GJ-modulating agents using molecular docking allows accurate prediction binding affinities ligands, which, unfortunately, often poorly correlate with their potencies. obj...

4D quantitative structure-activity relationship (QSAR) and 3D pharmacophore models were built and investigated for cytotoxicity using a training set of 25 lamellarins against human hormone dependent T47D breast cancer cells. Receptor-independent (RI) 4D QSAR models were first constructed from the exploration of eight possible receptor-binding alignments for the entire training set. Since the tr...

Abstract: Background and Aim: In an effort of drug development in the area HIV, present work deals with 2D 3D QSAR thiazolidinone derivatives against HIV-RT activity as a powerful method for elucidation relationships between structure activity. Materials Methods: were performed using MLR SA kNN respectively. Models which had higher predictability generated indicated from their statistical param...

A new computer program has been designed to build and analyze quantitative-structure activity relationship (QSAR) models through regression analysis. The user is provided with a range of regression and validation techniques. The emphasis of the program lies mainly in the validation of QSAR models in chemical applications. ARTE-QSAR produces an easy interpretable output from which the user can c...

The film shrinkage effect of photopolymeric phase media failed to provide the desired volume holograms for point-to-point optical interconnects. In this paper, we report a new compensation method to physically correct the shrinkage effect resulted from the holographic recording and the post baking. Dupont photopolymer HRF-600X001 is studied. The correction of the Bragg diffraction angle shift o...

This research aimed to investigate the use of fan type hologram, that is considered be a new technology, replace conventional billboard. Billboard usage consumes plenty energy and not flexible. Fan hologram expected reduce electricity becomes more attractive general society. Prototype system build with solar cell as source energy, battery storage. The from sun also measured confirmed supply eno...

Abstract In this paper, we present two approaches for recording a quasi-hologram on the steel surface by femtosecond laser pulses. The process is done rotating polarization of beam half-wave plate or spatial light modulator (SLM), so can control orientation formed laser-induced periodic structures (LIPSS). Two different are shown, which use vector and bitmap images to record hologram. For first...

Digital holography is a valuable tool for three-dimensional information extraction. Among existing configurations, the originally proposed set-up (i.e. Gabor, or in-line holography), is reasonably immune to variations in the experimental environment making it a method of choice for studies of fluid dynamics. Nevertheless, standard hologram reconstruction techniques, based on numerical light bac...