Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most common cause of cancer-related mortality worldwide. Due to the poor prognosis and limited therapeutic options, there is great interest in further understanding better the molecular underpinnings and potential molecular targets associated with HCC. The Hippo (Hpo) signaling pathway and YAP, its principal downstream...

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This review aims at defining the neuroendocrine mechanisms underlying sport-induced restrictions of reproductive axis in female athletes. Episodic gonadotropin release was found to be compromised, presumably a result impaired hypothalamic pulsatile GnRH release. Any deviation from optimal may suboptimal function ovaries, leading disorders menstrual cycle and ovulation. A whole spectrum dysfunct...

Obesity has a negative effect on reproductive potential due to functional changes in the Hypothalamo-Pituitary-Ovarian (HPO) axis. Obesity is often associated with hyperinsulinemia,a known stimulus for increased androgen production.8 Androgens get converted to oestrogen (Og) in periphery namely in Adipose tissue (AT) present in excess=> negative feedback on the HPO axis and thus affecting gonad...

Minimum-energy geometries and relative electronic energies of the X (1)A(') and A (1)A(") states of HPO have been computed employing the coupled-cluster single-double plus perturbative triple excitations {RCCSD(T)} and/or complete-active-space self-consistent-field (CASSCF) multireference internally contracted configuration interaction (MRCI) methods with basis sets of up to the augmented corre...

BACKGROUND Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is thought to be associated with more mood symptoms and worse cognitive functioning. This study examined whether variation in HPA axis activity underlies the association between mood symptoms and cognitive functioning. METHODOLOGY/PRINCIPAL FINDINGS In 65 bipolar patients cognitive functioning was measured in domains of...

The adsorption of dissolved organic matter (DOM) on granular-activated carbon (GAC) as a pretreatment to reverse osmosis (RO) desalination of membrane bioreactor (MBR) effluents was studied in lab- and pilot-scale columns. The pattern and efficiency of DOM adsorption and fate of the hydrophobic (HPO), transphilic (TPI) and hydrophilic (HPI) fractions were characterized, as well as their impact ...

Addition of 0.1-0.5 mM sodium PP(i) for 17 hr to confluent cultures of BALB/c 3T3 cells in low serum concentrations stimulated the incorporation of [(3)H]thymidine into DNA to an extent equal to that produced by high serum concentration. PP(i) prevented much but not all of the cell detachment that accompanies decreasing the serum concentration of confluent cultures and it increased the saturati...

A series of synthetic analogues of d-GlcN alpha 1-6-d-myo-inositol-1-HPO(4)-sn-1,2-dipalmitoylglycerol, consisting of 22 variants of the d-GlcN or lipid components, were tested in trypanosomal and human (HeLa) cell-free systems. The assays measured the abilities of the analogues to act as substrates or inhibitors of the enzymes of glycosylphosphatidylinositol biosynthesis downstream of GlcNAc-p...

The putative spin-triplet superconductor UTe2 has an Ising-like magnetic anisotropy, indicating the Cooper pair spins parallel to easy-axis. However, upper critical field for hard-axis direction is much larger than that easy-axis, implying strong suppression of Pauli depairing effect even direction. This observation consistent with recent NMR measurements which show tiny decrease Knight shift b...