3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium. Despite many proposed therapeutic applications, the safety profile of 3'-HPT has not been established. The present work investigated 90 day repeated oral dose and reproductive (developmental) toxicity of 3'-HPT as a test substance in rats as per OECD guidelines. 90 day toxicity ...

PURPOSE This study aimed to investigate the therapeutic potential of hydrogen-rich saline on pancreatic ischemia/reperfusion (I/R) injury in rats. METHODS Eighty heterotopic pancreas transplantations (HPT) were performed in syngenic rats. The receptors were randomized blindly into the following three groups: the HPT group and two groups that underwent transplantation and administration of hyd...

BACKGROUND We previously reported a significant association between plasma leptin (LPT) concentration and blood pressure (BP), which was partly independent of serum insulin levels and insulin resistance. The aims of this study were to detect whether serum LPT levels predict the development of hypertension (HPT) in the 8-yr follow-up investigation of a sample of an adult male population (the Oli...

IMPORTANCE Dry eye disease (DED) is common, but little is known about factors contributing to symptoms of dry eye, given the poor correlation between these symptoms and objective signs at the ocular surface. OBJECTIVE To explore whether pain sensitivity plays a role in patients' experience of DED symptoms. DESIGN, SETTING, AND PARTICIPANTS A population-based cross-sectional study of 1635 fe...

Propylene glycol (propane-1,2-diol; PD) is a widely used solvent for intravenous drugs. Clinical studies have reported serious side effects, including the development of renal insufficiency in patients receiving PD as drug vehicle. Despite such clinical reports, the data on the toxicity of PD in isolated renal cells are limited. Using primary cultured human proximal tubule (HPT) cells as an in ...

In this study, a composite with alternate layers of 5056 and 1580 alloys was manufactured wire arc additive manufacturing technology. It is shown that increased strength characteristics material can be obtained deformation treatment using high-pressure torsion (HPT) technique. The microstructure mechanical properties the HPT-processed in different structural states were investigated. exhibits h...

HYPOTHESIS Sporadic primary hyperparathyroidism (1 HPT) in young persons is thought to be extremely rare. The exact incidence is unknown and little is known of the characteristics of the disease. METHODS From 1976 to 1998, 33 patients aged 19 years or younger underwent operation for sporadic 1 HPT at a single institution. Data were recorded regarding the clinical, surgical, pathologic, and bi...

OBJECTIVE This paper is aimed at to evaluate B7-H1 expression as induced by human cytomegalovirus (HCMV) in extravillous cytotrophoblast cell line HPT-8 and possible underlying mechanism. METHOD Real time PCR and flow cytometry were used to determine B7-H1 mRNA and protein before and after HCMV infection in HPT-8 cells. Western blot analysis was used to determine the level of MAPK phosphoryla...

By analyzing the problem of high pressure torsion (HPT) in the rigid plastic formulation, we show that the power hardening law of plastically deformed materials leads to self-similarity of HPT, admitting a simple mathematical description of the process. The analysis shows that the main parameters of HPT are proportional to β q , with β being the angle of the anvil rotation. The meaning of the p...

The research on structural features, microhardness distribution, and deformation features of Vit105 bulk metallic glass (BMG) before after high-pressure torsion (HPT), as well relaxing annealing, has been carried out. HPT n = 1 leads to an increase in free volume ?V, annealing a decrease ?V non-uniformity relative the initial state BMG. In BMG is uniformly distributed over surface, while materi...