Fitness for work assessment is inherent to occupational medicine practice, whether at the pre-employment stage, or when a person is an established employee. Many occupational health practitioners are involved in the assessment of fitness of workers to undertake safety critical work, for example, driving a heavy goods vehicle or a train or working in health care. But, how do we define safety cri...

Regulatory agencies recommend that centrally active drugs are tested for abuse potential before approval. Standard preclinical assessments are conducted in rats or non-human primates (NHPs). This study evaluated the ability of the zebrafish conditioned place preference (CPP) model to predict human abuse outcomes. Twenty-seven compounds from a variety of pharmacological classes were tested in ze...

BACKGROUND Large health care databases are a valuable source of infectious disease epidemiology if diagnoses are valid. The aim of this study was to investigate the accuracy of the recorded diagnosis coding of herpes simplex encephalitis (HSE) in the Danish National Patient Registry (DNPR). METHODS The DNPR was used to identify all hospitalized patients, aged ≥15 years, with a first-time diag...

To understand the function of multiple heat shock transcription factors in higher eukaryotes, we have characterized the interaction of recombinant mouse heat shock transcription factors 1 and 2 (mHSF1 and mHSF2) with their binding site, the heat shock element (HSE). For our analysis, we utilized the human HSP70 HSE, which consists of three perfect 5'-nGAAn-3' sites (1, 3, and 4) and two imperfe...

Investment in mineral industries always deals with various economic, political, technical, and environmental risks. Not paying enough attention to such risks increases the possibility of investment failure. Accordingly, this study, risk criteria for investing sub-criteria assessment according type industries, including exploration, exploitation, processing projects, have been identified priorit...

In the United Kingdom the diagnosis of Hand-arm Vibration Syndrome varies depending on the purpose of that diagnosis. The criteria differ in three situations. More than 100,000 miners and ex-miners with claims for HAVS have been examined using a Medical Assessment Process which included the use of standardised tests. This contract is unique but it has had significant effects on the two other pr...

Recently, a novel approach towards semi-quantitative IT security risk assessment has been proposed in the draft IEC 62443-3-2. This approach is analyzed from several different angles, e.g. embedding into the overall standard series, semantic and methodological aspects. As a result, several systematic flaws in the approach are exposed. As a way forward, an alternative approach is proposed which ...

Herpes simplex encephalitis (HSE) is a severe neurological disease in children and adults caused by herpes simplex virus. This review discusses recent findings on the role of Toll-like receptor 3 (TLR3) deficiencies in the HSE development. Critical checkpoints in the TLR3 signaling that contribute to innate response are discussed, including the importance of TLR3 ligand recognition site and tra...

Activation of human heat shock gene transcription by heat shock, heavy metal ions, and amino acid analogs required the heat shock element (HSE) in the HSP70 promoter. Both heat shock- and metal ion-induced HSP70 gene transcription occurred independently of protein synthesis, whereas induction by amino acid analogs required protein synthesis. We identified a HSE-binding activity from control cel...

ABSTRACIThis review surveys research dealing with the Mean Density Approximation (MDA) and the Hard Sphere Expansion (HSE) theory developed by Leland and coworkers. MDA and its modifications provide a simple way to predict radial distribution functions of mixtures from the pure fluid information. Comparisons with computer simulation data show the MDA to be superior to the van der Waals approxim...