Background: Platelets can activate B cells and stimulate them for the production of antibodies. Since platelet microparticles (PMPs) originate from platelets, they may have the same virtue. In the present study, the effect of PMPs was investigated on the production of human leukocyte antigen (HLA)-specific antibody from B cells in vitro. Materials and Methods: In this experimental study, HLA-D...

MS is a chronic heterogeneous demyelinating disease of the CNS among young population, manifested by unpredictable attacks and subsequent remissions (McGinley et al., 2021; Lublin 2022). The develops as result an interaction between genetic environmental factors (Dobson 2019). most important risk factor are alleles genes encoding human leucocyte antigens (HLAs), especially HLA-DRB1*1501 (Hollen...

A human serum (obtained from a multiparous and multiple-transfused patient with chronic myelogenous leukemia) and a rabbit antiserum (obtained by immunization with papain extracts from a B-lymphoblastoid cell line) showed reactivity against antigenic specificities (different from HLA) expressed on peripheral blood B-lymphocytes, unmarked lymphocytes, and monocytes. These antigenic determinants ...

In the last two decades, anatomic compartmentalization of T and B cells within lymphoid tissues has been demonstrated in a wide variety of species, including man (1-5). T cells are located in the paracortical or interfollicular regions of lymph nodes and in the lymphoid tissues of the intestine and tonsil, whereas in the spleen, T cells are found primarily in the periarteriolar region of the Ma...

Peripheral blood lymphocytes from normal subjects as well as patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and active tuberculosis were studied for the relative distribution of bone marrow-derived lymphocytes (B-cells) and thymic-derived T-cells. B-cells were identified by direct immunofluorescence of surface Ig markers; T-cells were studied using rabbit antisera ...

Bleomycin (BLM) as an anti-cancer agent causes tissue toxicities through DNA damaging and cell deaths. The aim of this study was to investigate the effects of thymol against genotoxicity and anti-proliferation induced by BLM in normal human lymphocytes and ovarian cancer cells. Peripheral blood samples were collected from human volunteers and were incubated with thymol at different concentratio...