context maternal serum human chorionic gonadotropin (hcg) and alpha fetal protein (afp) were originally introduced to detect trisomy 21 and neural tube defects. however, in the absence of aneuploidy or neural tube defects, mid-trimester maternal serum hcg and/or maternal serum afp associated with adverse pregnancy outcomes. pregnancies with unexplained mid-trimester elevation in maternal serum ...

Choriocarcinoma is a curable malignancy that occurred approximately 50% after term pregnancies, and prognosis in this form of gestational trophoblastic Disease (GTD) is Poor. The earliest onset choriocarcinoma after term pregnancy in one study was reported 3 weeks after delivery, but in current study, choriocarcinoma was diagnosed 2 weeks after delivery. 28 years-old women gravidity 2, parity 2...

Treatment with colchicine or x-radiation of a human embryonal carcinoma of testicular origin, which has secreted a chorionic gonadotropin-like hormone in ~0 per cent of heterografted hosts, resulted in a 2 89 times increase in the incidence of chorionic gonadotropin-secreting tumors as determined in oophorectomized and hypophysectomized animals. Lines developed from three of the tumors treated ...

We studied the in vitro effect of dipyrone on the determination of free triiodothyronine (free T3), cortisol, progesterone, estradiol, carcinoembryonic antigen, human chorionic gonadotropin and alpha-fetoprotein measured with an immunoenzyme assay based on enhanced luminescence that uses peroxidase as label. We found significant interference from dipyrone (p < 0.01) in the determination of all ...

The role of surgery in the treatment of patients with metastatic choriocarcinoma has diminished. We present a case of chemo-resistant metastatic choriocarcinoma salvaged by surgery. A 48-year-old patient presented with uterine perforation and severe intractable hemorrhage, and histological examination revealed a choriocarcinoma. After 6 years of disease-free state, recurrence occurred in the re...

Gonadotropins are routinely administered to produce multiple oocytes for clinical in vitro fertilization (IVF) treatment, laboratory research, and livestock industries. Studies in mice have shown gonadotropin stimulation using equine chorionic gonadotropin (eCG) affects the endometrium, implantation, and fetal development. Evidence from clinical studies also indicates that stimulation with reco...

Choriocarcinoma is a highly invasive and metastatic neoplasm which arises in women of reproductive age. It can be either gestational or nongestational in origin, but the latter form is very rare. Choriocarcinoma is characterized by the production of human chorionic gonadotropin. It can metastasize to distant organs such as lung, brain, liver, kidney, and vagina in the early stages of disease, b...

Treatment with colchicine or x-radiation of a human embryonal carcinoma of testicular origin, which has secreted a chorionic gonadotropin-like hormone in ~0 per cent of heterografted hosts, resulted in a 2 89 times increase in the incidence of chorionic gonadotropin-secreting tumors as determined in oophorectomized and hypophysectomized animals. Lines developed from three of the tumors treated ...