Some years ago, we found that Axial organ (AO) cells exerted an induced and spontaneous cytotoxicity against SP2 MBL2 mouse tumoral cells. Recently, discovered a sea star Igkappa gene with immune properties. This was first, inserted in CMV (cytomegalovirus) finally plasmid called « young » plasmid. In the present experiment IGKappa cloned HeK human to produce specific protein. The induced« prot...

BACKGROUND Congenital cytomegalovirus infections are a leading cause of neurodevelopmental disorders in human and represent a major health care and socio-economical burden. In contrast with this medical importance, the pathophysiological events remain poorly known. Murine models of brain cytomegalovirus infection, mostly neonatal, have brought recent insights into the possible pathogenesis, wit...

Cytomegalovirus (CMV) is an important pathogen in HIV (Human Immunodeficiency Virus) patients, as it could drive accelerated disease progression leading to increased morbidity and mortality the population. This cross-sectional study analyzed plasma samples from 93 positive participants Rivers State University Teaching Hospital, Port Harcourt, Nigeria, investigate magnitude associated factors of...

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) detection on Bronchoalveo...

We have developed and tested a method for printing protein microarrays on glass slides and using these microarrays in a comparative fluorescence assay to detect TORCH infections. We generated protein microarrays by printing antibodies to simultaneously determine infections of TORCH (toxoplasmosis-rubella-cytomegalovirus-herpes) by detecting antibodies against Toxoplasma gondii, rubella virus, c...

The severe shortage of human organs for transplantation is the driving force behind xenotransplant research. Nonhuman primates, particularly baboons, are potential sources of organs and tissues. Human cytomegalovirus (HCMV) is the most common donor-associated infection after allotransplantation. Baboon cytomegalovirus (BCMV) is endemic in baboon populations and therefore is a potential cause of...

Vonka, Vladimir (Baylor University College of Medicine, Houston, Tex.), and Matilda Benyesh-Melnick. Interactions of human cytomegalovirus with human fibroblasts. J. Bacteriol. 91:213-220. 1966.-Virus attachment of human cytomegalovirus to human embryo lung fibroblasts was found to be temperature-independent, from 4 to 37 C. Prolonged incubation at 4 C, however, resulted in inactivation of a hi...