The subspecialty of cardio-oncology aims to reduce cardiovascular morbidity and mortality in patients with cancer or following treatment. Cancer therapy can lead a variety complications, including left ventricular systolic dysfunction, pericardial disease, valvular heart disease. Echocardiography is key diagnostic imaging tool the diagnosis surveillance for many these complications. baseline as...

Background T cells recognize cancer cells via human leukocyte antigen (HLA)/peptide complexes, and class I HLA restricted tumor infiltrating T cells correspond to favorable prognoses in several cancers, including ovarian cancer. Cancerspecific HLA/peptide complexes therefore represent tumor cell surface biomarkers, and the accurate identification of HLA/peptide targets is a prerequisite for the...

PURPOSE We studied the safety, tolerability, and recommended dose of BMS-599626, an orally bioavailable inhibitor of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. PATIENTS AND METHODS Patients with advanced solid tumors that expressed epidermal growth factor receptor (EGFR) and/or HER-2 were recruited and enrolled in a phase I, open-label, dose escalati...

Pyruvate kinase type M2, which is expressed in multiple tumor cell types and plays a key role in aerobic glycolysis, also has nonglycolytic functions and can regulate transcription and cell proliferation. The results of this study show that epidermal growth factor receptor activation induces pyruvate kinase type M2 nuclear translocation. To further determine the relationship between pyruvate ki...

Objective: When metastasis develops in some breast cancer patients, hormone receptors (HR) and Human Epidermal Growth Factor-2 (Her-2) status can change the tumor alters its character. We tried to determine rate of these changes biology 110 patients that we followed our clinic performed biopsy from metastatic site (re-bx). aimed biological tumors and, contribute literature by examining relation...

Overexpression of the epidermal growth factor receptor family member Her-2/neu in breast cancer is associated with poor prognosis. With evidence accumulating for a chemopreventive role of green tea polyphenols, the effects of epigallocatechin-3 gallate (EGCG) on Her-2/neu-overexpressing breast cancer cells were examined. EGCG inhibited mouse mammary tumor virus (MMTV)-Her-2/neu NF639 cell growt...

PURPOSE This study is to investigate the estrogen receptor β (ERβ) expression in molecular subtypes of breast cancer and clinic significance of ERβ expression. METHOD The ERβ expression was detected in 730 cases of breast cancer tissue specimens by immunohistochemistry. Twenty-one patients were censored during 2-10 years follow-up. The difference in ERβ expression was analyzed by Pearson Chi-...

results a low adc value was associated with lymph node metastasis (p < 0.01) and with high ki-67 protein levels (p = 0.03). there were no significant differences in the adc values among the histological grade (p = 0.48), molecular subtype (p = 0.51), tumor size (p = 0.46), and p53 protein level (p = 0.62). conclusion the pre-operative use of the 3.0 tesla dwi could provide information about the...