background: clinical evidence indicates the diabetes-induced impairment of osteogenesis caused by a decrease in osteoblast activity. flavonoids can increase the differentiation and mineralization of osteoblasts in a high-glucose state. however, some flavonoids such as luteolin may have the potential to induce cytotoxicity in osteoblast-like cells. this study was performed to investigate whether...

The presence of stem cells in leukemia and solid tumors has been demonstrated in recent decades. Cancer stem cells have the potency of tumorigenesis; furthermore, they have the ability of self-renewing and differentiation like other stem cells. They also play important role in the process of tumor invasion and metastasis. Several studies have been performed to discover the spe...

Strategies of Schwann cell (SC) transplantation to regenerate the peripheral nerve injury involves many limitations. Stem cells can be used as alternative cell sources for differentiation into SCs. Given the high potential of neural crest-derived stem cells for the generation of multiple cell lineages, in this research, we considered whether olfactory ecto-mesenchymal stem cells (OE-MSCs) derive...

objective: cd133+ umbilical cord blood cells were identified as a hematopoietic stem cell which has the capacity for extensive self-renewal and differentiation. the aim of this study was to identify the effect of staurosporine (sts), a wellknown protein kinase inhibitor on differentiation of cd133+ cells into neural cells. materials and methods: cd133+ cells were enriched by immunomagnetic bead...

PM-11. DEVELOPMENT OF A HUMAN MENINGIOMA MOUSE XENOGRAFT MODEL WITH THE SPONTANEOUSLY IMMORTAL CELL LINE KCI-MENG1 Sharon Michelhaugh1, Anthony Guastella1, KaushikVaradarajan1, Lisa Polin1,2, Aliccia Bollig-Fischer1,2, Fazlul Sarkar1,2, and Sandeep Mittal1,2; Wayne State University, Detroit, MI, USA; Karmanos Cancer Institute, Detroit, MI, USA BACKGROUND: There is a paucity of effective therapi...

bone marrow mesenchymal stem cells can differentiate into neurons and astrocytes after transplantation in the spinal cord injury of rats. although bone marrow mesenchymal stem cells are known to protect against spinal cord injury through anti-apoptotic effects, but generation of neural stem cells with large number and safety protocols unclear. in the present study, described the differentiation...

research about potential use of stem cells for the development of germ line cells in vitro had been challenged. in the present study, we reported a novel protocol consisting of cocktail growth factor addition for germ cell differentiation followed by transfection. the cells were purificated based on the expression on the cell surface of a protein. this protein is not present in normal cells of ...