Insulin-like growth factor (IGF)-binding proteins (IGFBPs) either inhibit or enhance IGF-stimulated cellular effects. While inhibition occurs by sequestration of IGF from cell-surface receptors, the exact mechanism of IGF-enhancement remains undefined. Human osteoblast-like bone cells in culture secrete several IGF-binding proteins, one of which we have previously identified as IGFBP-5. In this...

The plasma immersion ion implantation and deposition (PIIID) technique was used to implant zinc (Zn) ions into smooth surfaces of pure titanium (Ti) disks for investigation of tooth implant surface modification. The aim of the present study was to evaluate the surface structure and chemical composition of a modified Ti surface following Zn ion implantation and deposition and to examine the effe...

There have been a number of attempts to modify the surface of dental implants to improve osseointegration. These modifications include alterations of surface chemistry and roughness. The purpose of this study was to examine the early response of human osteoblast-like cells placed on Ti-6Al-7Nb disks that had a similar grooved surface topography and three different levels of surface roughness (R...

This study was amid to biogenic synthesis of Silver Nanoparticles (AgNPs) and evaluated its chemical-physical biomedical properties. The currently used reducing agent is Polyalthia sclerophylla (CEPS). As a reducer, crude extract leaves (CEPS) used, while silver nitrate (AgNO3) as an initiator. Two samples were prepared named AgNPs-a AgNPs-b, respectively. carried out characterize their biologi...

introduction: brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. materials and methods: human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

Particulate wear debris can induce the release of bone-resorbing cytokines from cultured macrophages and fibroblasts in vitro, and these mediators are believed to be the cause of the periprosthetic bone resorption which leads to aseptic loosening in vivo. Much less is known about the effects of particulate debris on the growth and metabolism of osteoblastic cells. We exposed two human osteoblas...