showing the occurrence of glass/rubber transition in bovine serum albumin (a globular protein) atlow moisture levels and the occurrence of maillard crosslinking in gelatin in previous works, the importanceof the state of glass or rubber of bsa on the rate and extent of polymerisation, protein solubility, colour andsds page patterns in the presence and absence of ascorbic acid, diketogulonic aci...

conclusions in this study, a low albumin level (≤ 3 mg/dl) was an indicator of nutritional status. patients’ albumin levels, bmi, nutritional status, apache ii score, and sofa score were associated with mortality. age in itself did not predict mortality in the elderly. objectives in this study, the effect of body mass index (bmi) and albumin values at first admission to the icu on the course an...

background: hypoalbuminemia may be caused by liver disease, nephrotic syndrome, burns, protein-losing entropathy, malnutrition, and metabolic stress. alterations in albumin in metabolic stress such as cardiac surgery have been previously investigated. we studied serum albumin concentration in children with congenital heart disease and also the association of hypoalbuminemia with mortality and m...

The daily intravenous administration of 50 gm. of concentrated saltpoor human serum albumin’ produces a rise in serum albumin level and a decline in urinary calcium and phosphorus excretion (1). These latter changes have been interpreted as evidence for an albumin-induced stimulation of osteogenesis (2). The consistent finding of a concomitant depression of serum alkaline phosphatase activity w...

With the overall objective of assessing the potential of utilizing plasma protein binding interactions in combination with the prodrug approach for improving the pharmacokinetics of drug substances, a series of model carbonate ester prodrugs of phenol, encompassing derivatives with fatty acid-like structures, were characterized in vitro. Stability of the derivatives was studied in aqueous solut...

dietary flavonoids show beneficial effects in the prevention of chronic diseases. however, flavonoid bioavailability is poor, probably due to their interaction with serum albumins. in the current work, the binding interactions of eight related flavonoids, sharing a similar core structure, with bovine serum albumin (bsa) were investigated by fluorescence spectroscopy. the binding affinities of t...