Studies were made of the growth and therapeutic response of three lines of human tumor serially transplanted in immune-suppressed mice. They included a well-differentiated colonic carcinoma (HX 13), a poorly differentiated colonic carcinoma (HX 18), and undifferentiated small-cell carcinoma of the bronchus (HX 29). Their histological appearance and growth rates were stable, with volume-doubling...

Unlike fungal and bacterial diseases, no direct method is available to control viral diseases. The use of resistance-inducing compounds can be an alternative strategy for plant viruses. Here we studied the basal response of melon to Melon necrotic spot virus (MNSV) and demonstrated the efficacy of hexanoic acid (Hx) priming, which prevents the virus from systemically spreading. We analysed call...

Amide hydrogen exchange (HX) is widely used in protein biophysics even though our ignorance about the HX mechanism makes data interpretation imprecise. Notably, the open exchange-competent conformational state has not been identified. Based on analysis of an ultralong molecular dynamics trajectory of the protein BPTI, we propose that the open (O) states for amides that exchange by subglobal flu...

Conventional convolutional neural networks use either a linear or a nonlinear filter to extract features from an image patch (region) of spatial size Hx W (typically, H is small and is equal to W, e.g., H is 5 or 7 ). Generally, the size of the filter is equal to the size Hx W of the input patch. We argue that the representational ability of equal-size strategy is not strong enough. To overcome...

Oligonucleotide models of ribosomal RNA domains are powerful tools to study the binding and molecular recognition of antibiotics that interfere with bacterial translation. Techniques such as selective chemical modification, fluorescence labeling and mutations are cumbersome for the whole ribosome but readily applicable to model RNAs, which are readily crystallized and often give rise to higher ...

A new class of helium-cooled high heat-flux plasma facing heat exchanger (HX) concept is presented. These unique “Foam-In-Tube” HX concepts are composed of a thin tungsten shell integrally bonded to an open-cell tungsten foam core. High heat flux tests show maximum heat loads of 22.4 MW/m using 4 MPa helium at a flow rate of 27 g/s. Based on these impressive performance results, a unique and sc...

Let C be a full dimensional, closed, pointed and convex cone in a nite dimensional real vector space E with an inner product hx;yi of x; y 2 E , andM a maximal monotone subset of E E . This paper studies the existence and continuity of centers of the monotone generalized complementarity problem associated with C and M: Find (x;y) 2 M\ (C C ) such that hx;yi = 0. Here C = fy 2 E : hx;yi 0 for al...

The resistance of fall armyworm (FAW), Spodoptera frugiperda, has been characterized to some Cry and Vip3A proteins of Bacillus thuringiensis (Bt) expressed in transgenic maize in Brazil. Here we evaluated the effective dominance of resistance based on the survival of neonates from selected Bt-resistant, heterozygous, and susceptible (Sus) strains of FAW on different Bt maize and cotton varieti...

Spectral properties of 1-D Schrödinger operators HX,α := − d 2 dx2 + ∑ xn∈X αnδ(x − xn) with local point interactions on a discrete set X = {xn}n=1 are well studied when d∗ := infn,k∈N |xn − xk| > 0. Our paper is devoted to the case d∗ = 0. We consider HX,α in the framework of extension theory of symmetric operators by applying the technique of boundary triplets and the corresponding Weyl funct...

We evaluated the enhancement of cured meat taste during maturation by sensory analysis. We focused on the heat-stable sarcoplasmic fraction (HSSF) to identify the factors related to cured meat taste. Because the dry matter of HSSF contained more than 30% nitrogen, nitrogen compounds such as free amino acids, small peptides and adenosine triphosphate-related compounds seemed to be the important ...