A hybrid cluster (HC) is a 4Fe with both sulfur and oxygen bridges. Hybrid proteins (Hcps) contain two clusters, one electron transferring iron-sulfur cluster. The structural gene, hcp, diffusely found in bacteria, archaea, monocellular eukarya, the HC binding motif involving amino acids H, E, C, (K) appears to be fully conserved. active site of enzyme Hcp. Of several reported Hcp enzymatic act...

The influenza A virus M2 polypeptide is a small integral membrane protein that does not contain a cleaved signal sequence, but is unusual in that it assumes the membrane orientation of a class I integral membrane protein with an NH2-terminal ectodomain and a COOH-terminal cytoplasmic tail. To determine the domains of M2 involved in specifying membrane orientation, hybrid genes were constructed ...

hepatitis b surface antigen is the first genetically engineered vaccine licensed for human use. various strategies have been proposed to obtain a vaccine that would bypass the need for injection. in this study, a non-toxic portion of heat-stable enterotoxin of escherichia coli that is capable of adhering to epithelial cells was inserted at amino acid position 112 of hepatitis surface antigen. t...