نتایج جستجو برای: hydroxy
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The four stereoisomers of the 2-hydroxy derivatives of digitoxigenin and 3-epidigitoxigenin have been synthesized, their structures established by NMR, and their binding affinity for the digitalis receptor on Na+, K(+)-ATPase evaluated. These derivatives showed lower affinities than the parent compounds. The hydrophilic hydroxy groups in the alpha position are more detrimental to the affinity t...
Investigation of allelopathic substances from herbal plants may lead to the development allelochemical-based natural herbicides. Croton oblongifolius (Roxb.) is a well-known plant with long history being used for traditional medicines and source diverse range bioactive compounds. This has been reported have potential; however, its allelopathic-related not yet described. Therefore, we conducted ...
In the title compound, C(16)H(23)NO(5), the H-N-O-C torsion angle is 98.6 (1)°, which is of a similar magnitude to other N,O-diacyl-hydroxy-lamines. The N-O distance is 1.4029 (14) Å, which is similar to the N-O distance in other N,O-diacyl-hydroxy-lamines. In the crystal, intermolecular N-H⋯O hydrogen bonds generate chains of molecules.
A new chemo-enzymatic route to both isomers of 2-hydroxy-4-phenylbutyric acid is reported. The key step is the lactonase-catalyzed hydrolysis of cis- and trans-2-hydroxy-4-phenyl-4-butyrolactones followed by hydrogenation over Pd/C to afford optically pure 2-hydroxy-4-phenylbutyric acid.
Enantiopure β-hydroxy sulfoxides and catechol sulfoxides were obtained, by chemoenzymatic synthesis, involving dioxygenase-catalysed benzylic hydroxylation or arene cis-dihydroxylation and cis-diol dehydrogenase-catalysed dehydrogenation. Absolute configurations of chiral hydroxy sulfoxides were determined by X-ray crystallography, ECD spectroscopy and stereochemical correlation. The applicatio...
(-)-alpha-Pinene (1), a major constituent of many aromatic plants was biotransformed by the plant pathogenic fungus, Botrytis cinerea to afford three new metabolites, characterized as 3beta-hydroxy-(-)-beta-pinene (10%) (3), 9-hydroxy-(-)-a-pinene (12%) (4), 4beta-hydroxy-(-)-alpha-pinene-6-one (16%) (5) by physical and spectroscopic methods. A known metabolite verbenone (2) was also obtained.
N-Hydroxy-T-fluoro^-acetylaminofluorene (A^-hydroxy-7fluoro-AAF) and Ar-hydroxy-2-acetylaminophenanthrene (A7hydroxy-AAP) were identified as urinary metabolites of 7-fluoro2-acetylaminofluorene and 2-acetylaminophenanthrene, respectively, in the rat. When administered as 0.010-0.012% of the diet for 10-15 weeks AT-hydroxy-7-fluoro-AAF proved to be a much more potent carcinogen for the rat than ...
DT-diaphorase catalysed the reduction of 1,4-naphthoquinones with hydroxy, methyl, methoxy and glutathionyl substituents at the expense of reducing equivalents from NADPH. The initial rates of quinone reduction did not correlate with either the half-wave reduction potential (E1/2) value (determined by h.p.l.c. with electrochemical detection against an Ag/AgCl reference electrode) or the partiti...
The electrocatalytic reduction of carbon dioxide (CO2) into added-value products is a promising alternative to completing the cycle atmospheric CO2. We report two new platinum complexes—a salen-like naphthalene (PtL1) and hydroxy-substituted salpn (PtL2)—that are capable activating CO2 produce monoxide (CO). predominant keto tautomer non-innocent ligands was determined using DFT calculations UV...
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine carcinogen prevalent in the human diet. To exert its mutagenic and carcinogenic effects, PhIP undergoes bioactivation to N-hydroxy-PhIP followed by O-esterification via cytosolic acetyltransferases or sulfotransferases to form DNA adducts. We investigated the role of cytosolic acetyltransferases and sulfotransferases...
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