Azadirachta indica leaves indicated the presence of active principles with proven antioxidants, antiinflammatory, immunomodulatory, free radical scavenging and healing properties. In the present study we evaluated the healing effects of 50% ethanol extract of dried leaves of Azadirachta indica on trinitrobenzene sulfonic acid-induced colitis in rats. Azadirachta indica extract (500 mg/kg) was a...

Dipeptidyl peptidase IV (EC 3.4.14.5; DPP IV), also known as the leukocyte differentiation antigen CD26 when found as an extracellular membrane-bound proline specific serine protease, cleaves a dipeptide from the N terminus of a polypeptide chain containing a proline residue in the penultimate position. Here we report that known (Z)-Ala-psi[CF=C]-Pro dipeptide isosteres 1 and 2, which contain O...

A new hydroxylamine sensor has been fabricated by immobilizing oxadiazol denvative at the surface ol aglassy carbon electrode (GCE) modified by multi-wall carbon nanotube (MIVCNT). The adsorbed thin Illms oroxadiazol derivative on the MWCNT modified GCE show a pair of peaks with surface confined characierisnus.The oxadiazol derivative MWCNI (OMWCNT) modified GCE shows highly catalytic activity ...

Bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. They were synthesized by different methods. Herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using Sulfonic acid functionalized silica (SiO2-Pr-SO3H) in aqueous media is reported. The advantages of this new metho...

Bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. They were synthesized by different methods. Herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using Sulfonic acid functionalized silica (SiO2-Pr-SO3H) in aqueous media is reported. The advantages of this new metho...

Treatment of polycytidylic acid with hydroxylamine produces an inactivation of its template properties as measured by incorporation of guanosine 5’-phosphate. Partial recovery of the guanosine 5’-phosphate incorporation can be obtained by the addition of adenosine 5’-triphosphate, but not @dine 5’4riphosphate or uridine 5’4riphosphate. Nearest neighbor studies showed that the adenosine 5’-phosp...

The surfactant assistant syntheses of sulfonic acid functionalized periodic mesoporous organosilicas with large pores are reported. A one-step condensation of tetramethoxysilane (TMOS) with 1,2-bis(trimethoxysilyl)ethane (BTME) and 3-mercaptopropyltrimethoxysilane (MPTMS) in highly acidic medium was performed in the presence of triblock copolymer Pluronic P123 and inorganic salt as additive. Du...

In the course of investigations regarding the effects of various chemical agents on neoplast,ic purine metabolism, it was observed that hydroxylamine prevents the accumulation of uric acid or allantoin that normally occurs upon incubation of crude tissue homogenates. Subsequent studies, reported in this paper, demonstrate that hydroxylamine is a competitive inhibitor of xanthine oxidase activit...

UNLABELLED Location of the sentinel lymph node in malignant melanoma and early breast cancer patients requires separate injections of radiocolloid and blue dye. These agents are administered at alternative times because of their different rates of transit. This study has elucidated why particular dyes are absorbed by the lymphatic system from an investigation of dye molecular structure as a fun...

Background Pain in patients with chronic pancreatitis is critical hallmark that accompanied inflammation, fibrosis, and destruction of glandular pancreas. Many researchers have demonstrated that stromal cell-derived factor 1 (also named as CXCL12) and its cognate receptor C-X-C chemokine receptor type 4 (CXCR4) involved in mediating neuropathic and bone cancer pain. However, their roles in chro...