نتایج جستجو برای: hydroxylase
تعداد نتایج: 16682 فیلتر نتایج به سال:
Human small intestine epithelial cells (enterocytes) provide the first site for cytochrome P450 (CYP)-catalyzed metabolism of orally ingested xenobiotics. CYP3A4 is the major form of CYP expressed in enterocytes and CYP2C is also expressed at a significant level. In this study, we further characterized the expression of CYP3A4 and CYP2C in human enterocytes and their interindividual variations ...
Hepatic prolyl hydroxylase activity and collagen synthesis were measured in patients with alcoholic liver disease to determine the feasibility of using the enzyme prolyl hydroxylase as a marker of hepatic fibrogenesis. Alcoholic patients with liver histopathology consistent with normal, steatosis, alcoholic hepatitis, early cirrhosis, or advanced cirrhosis were analysed for liver prolyl hydroxy...
Rat adrenal gland levels of dopamine &hydroxylase are subject to dual control. Activation of the splanchnic nerves to the adrenal medulla by reserpine induces the synthesis of dopamine /3-hydroxylase without altering the rate of enzyme degradation. In contrast, hypophysectomy causes a decline in steady state dopamine fi-hydroxylase levels by first accelerating the rate of degradation, then by s...
The genetic basis of aggressive behaviour has been examined extensively, including analysis genes encoding neurotransmitters, signalling molecules and regulatory enzymes, as well their synthesis degradation. Dopamine beta-hydroxylase, an enzyme catalysing the conversion dopamine into norepinephrine in synaptic endings, significantly affects modulation emotional states behaviour. aim this study ...
Stevia rebaudiana (Bert.) produces steviol glycoside sweeteners that are sweeter than sucrose. Stevioside and rebaudioside A important glycosides used in food production. This study was conducted to investigate the effect of different concentrations cadmium chloride (0, 20, 40, 60 80 mg/L) silver nitrate 15, 30, 45 sampling times on stevioside production Ent-kaurenoic acid 13-hydroxylase, uridi...
Parkinson’s disease (PD) is a neurodegenerative characterized by the progressive degeneration of dopaminergic neurons in substantia nigra. Oxidative stress-induced neuronal death has been identified as one major causes nigrostriatal PD. The fruit Actinidia arguta (A. arguta), known sarunashi Japan, reported to show beneficial health effects such antioxidant, anti-inflammatory, anti-mutagenic, a...
The mitochondrial enzyme 25-hydroxyvitamin D3-1a-hydroxylase (1a-hydroxylase) plays an important role in calcium homeostasis by catalyzing synthesis of the active form of vitamin D, 1,25-dihydroxyvitamin D3, in the kidney. However, enzyme activity assays indicate that 1a-hydroxylase is also expressed in a variety of extrarenal tissues; recent cloning of cDNAs for 1a-hydroxylase in different spe...
Background & Objective: Congenital Adrenal Hyperplasia(CAH) includes a group of inherited diseases which are caused by enzyme defects in the synthesis of cortisol from cholesterol. It manifests itself in different forms like ambiguous genitalia, adrenal crisis in infants, precocious puberty in children, hirsutism, oligomenorrhea and infertility in adults. Although CAH is one of the most com...
1 1 4 7 jci.org Volume 125 Number 3 March 2015 Introduction Collagen is the most abundant intrinsic matrix scaffolding protein and contributes to tissue tensile strength (1). Various aspects of collagen metabolism, including its expression, deposition, organization, and turnover, are aberrant in epithelial cancer and have been implicated in tumor progression (2). Evidence from multiple types of...
To analyze the protective effect and mechanism of beta-asarone from Acorus tatarinowii on neuron injury in rats with Parkinson's disease. Thirty five male Sprague Dawley were randomly selected to establish rat model The divided into 5 groups as sham operation group, low dose medium group high betaasarone 7 each group. Rats injected same amount normal saline, while middle 10 mg/kg, 20 mg/kg 40 r...
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