The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing aceclofenac. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelli...

This study developed an antibacterial oral gel to inhibit Streptococcus mutans, a bacterium that causes tooth decay. The was formulated using methanol extract of Piper betel leaves, hydroxypropyl methylcellulose and glycerin at different concentrations. evaluated for pH, viscosity activity against S. mutans standard methods. showed potent activity, supporting its use in the formulation. In sili...

The cellulose derivative hydroxypropyl methylcellulose (HPMC) has recently been extensively studied and used in mechanical applications. However, the softness susceptibility to deformation of HPMC limited its further In this study, metal nanoparticles (nano-aluminum nano-copper) nano-metal oxide particles (nano-alumina nano-copper oxide) were as additives form a composite film with improved pro...

Conventional extraction (CE) and microwave-assisted (MAE) were compared in terms of efficiency quality pectin two separate processes aimed to extract from Malus domestica ‘F?lticeni’ apple pomace. A similar yield a shorter time was observed for the procedure as CE, while galacturonic acid content degree esterification both methods. Apple extracted this plant source by methods had high content, ...

in the current study, floating dosage form containing acyclovir was developed to increase its oral bioavailability. effervescent floating tablets containing 200 mg acyclovir were prepared by direct compression method with three different rate controlling polymers including hydroxypropyl methylcellulose k4m, carbapol 934, and polyvinylpyrrolidone. optimized formulation showed good floating prope...

Calcium sulfate/calcium phosphate (CS-CP)-based bone substitutes have been developed in premixed putty for usage clinical applications. However, it is difficult to completely stop the bleeding during an operation because can come into contact with blood or body fluids leading disintegration. Under certain conditions depending on particle size and morphology, collapsed (washed) particles cause i...