Flaxseed oil has various benefits over multiple chronic diseases in humans and animals. Besides, flaxseed shown the potential to avert lipid disorders. However, researches have indicated that lower serum cholesterol animals human beings can be attributed whole oil. Therefore, this study aimed at determining effect of different levels on biochemical changes hypercholesterolemic rats. In study, (...

L-arginine a semi essential amino acid and a precursor of nitric oxide (NO) was orally supplemented in diet (standard rabbit feed) of hypercholesterolemic (n=6) and normal rabbits (n=6) for 16 weeks. Myocardial ischemia was produced in both groups of rabbits by subcutaneous single bolus injection of isoproteronol. Severity of myocardial ischemia was assessed by estimating the serum CPK and AST ...

Background: Rosa Canina L. is a medicinal plant with many therapeutic applications in traditional medicine. This study aimed to evaluate the effectiveness of the extract of Rosa Canina on liver function, lipid profiles and thyroid hormones in hypercholesterolemic rats. Methods: In this experimental study, 60 male Wistar rats were divided into...

Hypercholesterolemia and thrombosis have been implicated as factors in the development of atherosclerosis. Fibrinopeptide B (FPB) is a short chain peptide cleaved from fibrinogen during the production of fibrin. FPB is a known chemoattractant and has been shown to produce experimental atherosclerotic lesions in association with hypercholesterolemia. The present study was designed to examine the...

We studied the effects of hypercholesterolemia on vascular responsiveness in different arteries isolated from rabbits: control groups of rabbits and groups receiving the atherogenic diet consisted of eight animals each. In the arteries, 16 weeks of cholesterol-rich (0.3%) diet evoked intimal lesions which were more pronounced than those noted after 8 weeks of hypercholesterolemia; the aortic ar...

The effects of cholesterol-feeding in the presence of dipyridamole (0.60 g daily) on contractile responses and on endothelium-dependent and endothelium-independent relaxations in isolated rabbit aortas are described. The investigations were performed simultaneously with those described in Part I (Circ Res 1986; 58:552-564), where the effects of cholesterol feeding on vascular reactivity in rabb...

Maternal hypercholesterolemia during pregnancy is associated with enhanced fatty streak formation in human fetuses and faster progression of atherosclerosis during childhood even under normocholesterolemic conditions. A causal role of maternal hypercholesterolemia in lesion formation during fetal development has previously been established in rabbits. The same experimental model is now used to ...