The antimalarials are one of the most commonly prescribed drugs for conditions such as lupus erythematosus and rheumatoid arthritis, and the side effects, though infrequent, are well known. The antimalarial agent chloroquine diphosphate usually causes pigmentary changes in the oral mucosa characterized by a bluish-grey to black discolorations mainly in the hard palate. Considering only the hard...

Exogenous ochronosis is an infrequent dermatosis characterized as a dark blue hyperpigmentation localized where the causing agent was applied. It may be caused by the use of systemic medication such as antimalarials and by the use of topic substances such as phenol, resorcinol, benzene, or hydroquinone, which is a fenolic compound with depigmentation action, largely used in the treatment of mel...

Introduction . Bleomycin is a cytotoxic antibiotic that used as sclerosing agent for sclerotherapy of vascular anomalies. characterized by complications: nausea, vomiting, fever, the development allergies/anaphylaxis, skin discoloration (hyperpigmentation), damage to lung tissue. Aim To study frequency hyperpigmentation after administration bleomycin malformations with slow flow characteristics...

1498 CMAJ, September 18, 2012, 184(13) © 2012 Canadian Medical Association or its licensors A47-year-old black woman with chronic hepatitis C (genotype 4) was referred for hyperpigmentation of the tongue. She was a nonsmoker. Eight weeks after treatment with weekly injections of subcutaneous pegylated interferon α-2a and daily oral ribavirin was started for hepatitis C, asymptomatic dark brown ...

BACKGROUND Photoaged skin results from various environmental factors, most importantly chronic sun exposure. Dyschromia and fine lines/wrinkles are common clinical manifestations of photodamaged skin. PURPOSE This single-center clinical trial was conducted to assess the efficacy and tolerability of a new multifunctional facial primer (camouflage, broad-spectrum SPF 50, and a treatment for hyp...

INTRODUCTION Skin hyperpigmentation is common during pregnancy and often is due to endocrinological changes. Usual patterns include linea nigra, darkening of areola and melasma. We report a rare diffused hyperpigmentation condition in a pregnant woman of dark colored skin. CASE PRESENTATION A 19-year-old Tanzanian primigravida at 32 weeks gestation presented at our antenatal clinic concerned ...

BACKGROUND Flagellate hyperpigmentation is a well-documented complication of systemic bleomycin sulfate therapy when using doses of 100 U or more as an antineoplastic agent. Two cases occurred after using systemic doses from 15 to 30 U injected intravenously or intrapleurally; however, it has not been described as a complication following intralesional treatment of verruca plantaris. OBSERVAT...

Casein kinase 1α (CK1α), a component of the β-catenin destruction complex, is a critical regulator of Wnt signaling; its ablation induces both Wnt and p53 activation. To characterize the role of CK1α (encoded by Csnk1a1) in skin physiology, we crossed mice harboring floxed Csnk1a1 with mice expressing K14-Cre-ERT2 to generate mice in which tamoxifen induces the deletion of Csnk1a1 exclusively i...

Chemical peels are widely used in cosmetological and dermatological treatments. Salicylic acid Jessner’s solution often acne therapy. Moreover, both of these combination with retinol the therapy hyperpigmentation, wrinkles, photodamage, acne. The aim this research was to evaluate effectiveness treatment reduce lesions. Two 23-year-old women vulgaris lesions participated study. Each them receive...

BACKGROUND Transient hyperpigmentation is the most common complication seen following cutaneous carbon dioxide (CO2) laser resurfacing. OBJECTIVE The purpose of this study was to determine whether the use of a topical skin lightening regimen prior to cutaneous laser resurfacing reduces the incidence of post-laser resurfacing hyperpigmentation. METHODS One hundred consecutive CO2 laser resur...