The repeated administration of the hypolipidemic agent Su-13 437 (nafenopin) to neonatal rats roughly doubled the number of peroxisomes in the liver tissue and caused a sixfold volumetric expansion of the peroxisomal compartment. During the proliferative response, the size-distribution of the peroxisomes was reversibly altered, enlarged particles appearing in numbers varying according to the do...

Dyslipidemia is one of the main risk factors for development cardiovascular diseases (CVD), which remain leading cause death worldwide. Lipid level control most effective strategy prevention CVD and its complications (CVC). Statins are first-line drugs hypolipidemic therapy. often found in patients with chronic liver (CLD). From a clinical point view, number CLD have an increased CVD. Due to in...

In this article it will be discussed actual issues and modern problems of the ischemic disease heart, antiplatelet therapy, its effects, hypolipidemic indications, counter potential side effects as well as, successful management strategies after percutaneous coronary intervention following with drug eluted stents.

The hypoglycaemic and hypolipidemic effects of the aqueous extract of Ocimum basilicum (OB) whole plant were investigated in normal and streptozotocin (STZ) diabetic rats. After a single oral administration, OB significantly reduced blood glucose levels in normal (p<0.01) and diabetic rats (p<0.001). After 15 days of repeated oral administration, OB produced a potent reduction on blood glucose ...

We studied the mechanisms of hypolipidemic effects of NIP-200 (3,5-dimethyl-4,6-diphenyltetrahydro-2H-1,3,5-thiadiazine- 2-thione), a potent hypolipidemic compound, in cholesterol biosynthesis in the liver, cholesterol absorption in small intestine, and cholesterol catabolism and excretion in rats. NIP-200 did not reduce cholesterol biosynthesis and had no effects on cholesterol absorption in t...

Cardiovascular diseases continue to be a leading cause of morbidity and mortality in developed as well as developing countries. Hypercholesterolemia is one of the factors that have contributed in acceleration of Coronary Heart Diseases in India. It is associated with elevated lipid levels in the blood. Treatment of hypercholesterolemia is one of the major approaches towards decelerating the ath...

PURPOSE OF REVIEW The hypolipidemic and antiobesogenic effects of tea intake have been associated with bioactive compounds that regulate peroxisome proliferator-activated receptors (PPARs). This review describes the recent research on two of these compounds, (-)-epigallocatechin gallate (EGCG) and linalool. RECENT FINDINGS Catechins (specifically EGCG) are key bioactive compounds found in tea...