The genetic basis and cellular defects of a number of primary magnesium wasting diseases have been elucidated over the past decade. This review correlates the clinical pathophysiology with the primary defect and secondary changes in cellular electrolyte transport. The described disorders include (1) hypomagnesemia with secondary hypocalcemia, an earlyonset, autosomal-recessive disease segregati...

Hypomagnesemia and hypocalcemia are common adverse events during cetuximab treatment. The influence of the chemotherapeutic combination on serum levels is unknown and the predictive value is currently under discussion. This analysis investigated 79 patients who had received cetuximab for at least 6 weeks in the day clinic of the Comprehensive Cancer Center, University of Munich. Calcium and mag...

Introduction: Proton pump inhibitors are drug types frequently used for peptic ulcers and often prescribed with or without indication. Long-term use of PPIs (more than three months) can cause several adverse effects, including hypomagnesemia, a reduced serum magnesium level less 1.7 mg/dl.Methods: This cross sectional study analyzed ulcer outpatients who underwent endoscopy at Zainoel Abidin Ge...

BACKGROUND Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the rare complications associated with its use. CASE PRESENTATION A 42-year-old woman presented with a 20 year-history of hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria after cisplatin-based chemotherapy for ovaria...

A 71-year-old woman was referred to the endocrinology clinic after several years of unresolved hypomagnesemia that required numerous hospital admissions to receive intravenous magnesium. She previously presented with palpitations on 3 occasions, and once with diarrhea and vomiting. The blood tests on all 4 presentations demonstrated severe hypomagnesemia (Table 1). Her medical history included ...

Signs and Symptoms of Magnesium Depletion Symptomatic magnesium depletion is often associated with multiple biochemical abnormalities such as hypokalemia, hypocalcemia, and metabolic alkalosis. As a result, it is often difficult to ascribe specific clinical manifestations solely to hypomagnesemia. In 1960, five patients were reported with symptoms considered to be typical of magnesium depletion...