Stroke is a dynamic event in the brain involving heterogeneous cells. There is now compelling clinical evidence that prolonged, moderate cerebral hypothermia initiated within a few hours after severe ischemia can reduce subsequent neuronal death and improve behavioral recovery. The neuroprotective role of hypothermia is also well established in experimental animals. However, the mechanism of hy...

The last several years have seen an increased interest in the use of induced hypothermia after witnessed cardiopulmonary resuscitation (CPR). The main reason for its use is protection of the brain and hence, better neurological outcome in these patients. Therefore, induced hypothermia after CPR has become a part of standard recommendations in the 2005 Resuscitation Guidelines. At the same time,...

Permanent neurocognitive deficits due to cerebral sequelae account for the majority of longterm morbidity and mortality in survivors of cardiac arrest today. Albeit therapeutic hypothermia had been used as effective measure to ameliorate cerebral ischemia-reperfusion injury during surgery for decades, it was not yet introduced into regular post-arrest care until 2003 due to significant side eff...

Hypothermia is a major contributor to newborn mortality worldwide and remains a common problem for very low birthweight (VLBW) infants, even in technologically advanced hospital settings. The attributable risk of mortality from hypothermia is difficult to establish from the scant randomized trials on delivery room stabilization of VLBW newborns, but the relationship between admission temperatur...

Coagulopathy, acidosis and hypothermia form the lethal triad in trauma patients with acute hemorrhage. The prevention of this chain reaction relies on an adapted management from first care pre-hospital situation: rapid arrest bleeding, fight against hypothermia, limited vascular filling early recourse to vasoactive amines. Pre-hospital transfusion is still rare, whereas hospital, strategy can w...

OBJECTIVE To describe the use and feasibility of therapeutic hypothermia after pediatric cardiac arrest. DESIGN Retrospective cohort study. SETTING Pediatric tertiary care university hospital. PATIENTS Infants and children (age 1 wk to 21 yrs) without complex congenital heart disease with return of spontaneous circulation after in-hospital or out-of-hospital cardiac arrest from 2000 to 20...

Hypothermia is a condition in which core temperature drops below the level necessary to maintain bodily functions. The decrease in temperature may disrupt some physiological systems of the body, including alterations in microcirculation and reduction of oxygen supply to tissues. The lack of oxygen can induce the generation of reactive oxygen and nitrogen free radicals (RONS), followed by oxidat...

Accidental hypothermia is defined as an unintentional decrease in core body temperature to below 35 degrees C. Hypothermia causes hundreds of deaths in the United States annually. Victims of accidental hypothermia present year-round and in all climates with a potentially confusing array of signs and symptoms, but increasing severity of hypothermia produces a predictable pattern of systemic orga...

Hypothermia is generally defined as the body's internal temperature below 35 °C. Hypothermia is classified as primer and secondary hypothermia according to its mechanism, and as mild (32 to 35 °C), moderate (32-28 °C) and severe (below 28°C) hypothermia according to body temperature. The characteristic electrocardiographic finding of the hypothermia is the Osborn (j) wave, which is manifested a...