OBJECTIVE To assess the relationship between PiCCO-derived signals and conventional measures of pre-load and gas exchange in patients with septic shock. METHODS Prospective observational study of 23 patients with septic shock. Scheduled collection of clinical, conventional haemodynamic and PiCCO derived variables. Statistical analysis of correlations. RESULTS Patients had a mean SAPS II sco...

BACKGROUND Evaluation of causal relations between physical load and musculoskeletal disorders is hampered by the lack of knowledge as to the biological relevance of different loading parameters and the large variability between individuals. As indicators of molecular changes in the extracellular matrices of structures of the musculoskeletal system, biomarkers of collagen metabolism may provide ...

Background: Human T cell lymphotropic virus type I (HTLV-I)-associated myelopa-thy/tropical spastic paraparesis (HAM/TSP) is an inflammatory disease which occurs in less than 2% of HTLV-I -infected individuals. High proviral load, high HTLV-I-specific CD8+ cytotoxic T lymphocyte frequency (CTL) and host genetic factors such as HLA all appear to be associated with HTLV-I infection. Previous stud...

In a routine service delivery setting in Uganda, we assessed the ability of the WHO clinical stage to accurately identify HIV-infected patients in whom antiretroviral therapy should be started. Among 4302 subjects screened for ART, the sensitivity and specificity (95% CI) of WHO stage III, IV against a CD4 count < 200 x 106/l were 52% (50, 54%) and 68% (66, 70%) respectively. Plasma viral load ...

E cient resource usage is a key to achieve better performance in parallel database systems. Up to now, most research has focussed on balancing the load on several resources of the same type, i.e. balancing either CPU load or I/O load. In this paper, we present oating probe, a strategy for parallel evaluation of pipelining segments in a shared-everything environment that provides dynamic load ba...

EEcient resource usage is a key to achieve better performance in parallel database systems. Up to now, most research has focussed on balancing the load on several resources of the same type, i.e. balancing either CPU load or I/O load. In this paper, we present oating probe, a strategy for parallel evaluation of pipelining segments in a shared-everything environment that provides dynamic load ba...

BACKGROUND Dolutegravir (DTG; S/GSK1349572), a human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has limited cross-resistance to raltegravir (RAL) and elvitegravir in vitro. This phase IIb study assessed the activity of DTG in HIV-1-infected subjects with genotypic evidence of RAL resistance. METHODS Subjects received DTG 50 mg once daily (cohort I) or 50 mg twice daily (cohort...

Load distribution is commonly recognized as a useful technique to improve the performance of a distributed system. Much of the previous work on load distribution is performed in the context of process based operating systems executing on autonomous workstations. In this thesis we examine load distribution in the context of ne-grained object based operating systems and describe the design and im...