Two peroxidases (EC. 1.11.1.7), POD I and POD II were purified from the roots of cultivatedRaphanus sativus L. Var. Cicil by one step ion-exchange chromatography after fractionation by acetone. The molecular weight of these enzymes were 43000 and 41000 Daltons and RZ 1.2 and 2.0 for POD I and POD II, respectively. Both enzymes consisted of a single polypeptide chain on SDS-PAGE. The maximum...

PACS-CS Collaboration: Y. Kuramashi∗a,b†, S. Aokia,c, K.-I. Ishikawad, T. Ishikawab, N. Ishizukaa,b, K. Kanayaa, N. Tsutsuie, M. Okawad, Y. Taniguchia,b, A. Ukawaa,b, T. Yoshiéa,b, aGraduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan bCenter for Computational Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan cRiken BNL Research C...

IHL-305 is a PEGylated liposomal formulation of irinotecan (CPT-11). The objective of this study was to evaluate the factors associated with interpatient variability in the pharmacokinetics and pharmacodynamics of IHL-305 in patients with advanced solid tumors. IHL-305 was administered intravenously once every 4 weeks as part of a Phase I study. Pharmacokinetic studies of the liposomal sum tota...

OBJECTIVE To establish whether ADC and total choline were significantly different between cervical tumors with different histological characteristics (type, degree of differentiation, presence or absence of lymphovascular invasion, lymph-node involvement) in order to establish their role as predictive biomarkers. METHODS 62 patients with stage 1 cervical cancer were scanned at 1.5 T. T2-weigh...

PURPOSE To compare the clinical outcomes of intravitreal bevacizumab (IVB) injection, with different dosing (0.25 mg/0.01 ml versus 0.625 mg/0.025 ml) in each eye of the same patient with retinopathy of prematurity (ROP). METHODS Intravitreal bevacizumab (IVB) was injected into eight patients with stage 3+ in zone I or posterior zone II ROP (16 eyes). Bevacizumab, with different dosing (0.25 ...

Chini, Eduardo N. Selected Contribution: Effect of volatile anesthetics on cADP-ribose-induced Ca21 release system. J Appl Physiol 91: 516–521, 2001.— Volatile anesthetics have multiple actions on intracellular Ca21 homeostasis, including activation of the ryanodine channel (RyR) and sensitization of this channel to agonists such as caffeine and ryanodine. Recently it has been described that th...

A total of 305 female and 36 male SENCAR mice in six different groups were observed for 540 to 875 days for tumors as well as nonneoplastic lesions. Three of these groups were observed for their lifespans. The 123 females and 36 males, observed for their lifespans (800 to 875 days) showed median survival times ranging from 730 to 745 days. The average peak body weights were 42.4 g for females a...

R. Ichimiya, Y. Ikegami, Y. Ikemoto, T. Kohriki, T. Miyoshi, K. Tauchi, S. Terada, T. Tsuboyma, Y. Unno, Y. Horii, Y. Onuki, D. Nio, A. Takeda, K. Hanagaki, J. Uchida, T. Tsuru, S.G. Ryu, I. Kurachi, H. Kasai, N. Kuriyama, N. Miura, M. Okihara, M. Motoyoshi a Graduate School of Pure and Applied Sciences, Univ. of Tsukuba,Tsukuba, Ibaraki 305-8571, Japan b High Energy Accelerator Research Org.,T...

BACKGROUND In this study, we investigated the in vitro effects of calcium channel blockers (nifedipine, nitrendipine, isradipine, and amlodipine besylate) on the activity of paraoxonase-1 (PON1). METHODS PON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion-exchange and Sephadex G-200 gel filtration chromatography. RESULTS The calcium channel...