نتایج جستجو برای: icam 1

تعداد نتایج: 2752833  

2017
Wei Gu Lun Yao Lexing Li Jianping Zhang Aaron T. Place Richard D. Minshall Guoquan Liu

Intercellular adhesion molecule-1 is the adhesion molecule mediating leukocyte firm adhesion to endothelial cells, plays a critical role in subsequent leukocyte transmigration. ICAM-1 is also expressed in other cells including macrophages; however, the role of this adhesion molecule in mediating macrophage functions remains enigmatic. We report that ICAM-1 regulates macrophage polarization by p...

Journal: :Journal of virology 2002
Salim Bounou Jacques E Leclerc Michel J Tremblay

Human immunodeficiency virus type 1 (HIV-1) incorporates several host proteins. Earlier studies have indicated that such foreign constituents can modulate the virus life cycle, although the potential roles that these proteins might play in the viral pathology in vivo remain unclear. In an attempt to shed light on this issue, we first exposed explants of human lymphoid tissue to isogenic viruses...

Journal: :Journal of immunology 2005
Christian Blank Ian Brown Aalok K Kacha Mary A Markiewicz Thomas F Gajewski

ICAM-1 has been described to provide both adhesion and costimulatory functions during T cell activation. In the setting of antitumor immunity, ICAM-1/LFA-1 interactions could be important at the level of T cell priming by APCs in draining lymph nodes as well as for transendothelial migration and tumor cell recognition at the tumor site. To determine the contribution of ICAM-1 to tumor rejection...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2007
Lauren Taglia Damien Matusiak Kristina A Matkowskyj Richard V Benya

Gastrin-releasing peptide (GRP) and its receptor (GRPR) act as morphogens when expressed in colorectal cancer (CRC), promoting the assumption of a better differentiated phenotype by regulating cell motility in the context of remodeling and retarding tumor cell metastasis by enhancing cell-matrix attachment. Although we have shown that these processes are mediated by focal adhesion kinase (FAK),...

Journal: :Journal of immunology 2014
Roser Gorina Ruth Lyck Dietmar Vestweber Britta Engelhardt

In acute neuroinflammatory states such as meningitis, neutrophils cross the blood-brain barrier (BBB) and contribute to pathological alterations of cerebral function. The mechanisms that govern neutrophil migration across the BBB are ill defined. Using live-cell imaging, we show that LPS-stimulated BBB endothelium supports neutrophil arrest, crawling, and diapedesis under physiological flow in ...

Journal: :Infection and immunity 2006
Vasanthi Avadhanula Carina A Rodriguez Glen C Ulett Lauren O Bakaletz Elisabeth E Adderson

Nontypeable Haemophilus influenzae (NTHI) is an important respiratory pathogen. NTHI initiates infection by adhering to the airway epithelium. Here, we report that NTHI interacts with intracellular adhesion molecule 1 (ICAM-1) expressed by respiratory epithelial cells. A fourfold-higher number of NTHI bacteria adhered to Chinese hamster ovary (CHO) cells transfected with human ICAM-1 (CHO-ICAM-...

2017
Yuji Piao Verlene Henry Ningyi Tiao Soon Young Park Juan Martinez-Ledesma Jian Wen Dong Veerakumar Balasubramaniyan John F. de Groot

Intercellular cell adhesion molecule 1 (ICAM-1; also known as CD54) is overexpressed in bevacizumab-resistant glioblastoma. In the present study, we tested our hypothesis that highly expressed ICAM-1 mediates glioblastoma's resistance to antiangiogenic therapy. We validated ICAM-1 overexpression in tumors resistant to antiangiogenic therapy using real-time polymerase chain reaction, immunohisto...

Journal: :Journal of Health Sciences 2023

Introduction: The prevalence of metabolic syndrome (MetS) in Indonesia is 39% and it higher females than males (46% vs. 28%). Features this comprise low-grade chronic inflammation endothelial dysfunction from cardiometabolic abnormalities. High-sensitive C-reactive protein (HsCRP) a biomarker cardiovascular disease, whereas ferritin pentraxin-3 (PTX-3) are markers inflammation. One the an inter...

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