A complex set of extracellular signals is required for neural crest (NC) specification. However, how these signals function to coordinate cell-cycle progression and differentiation remains poorly understood. Here, we report in Xenopus a role for the transcription factor signal transducers and activators of transcription-3 (Stat3) in this process downstream of FGF signalling. Depletion of Stat3 ...

In the acoustic modeling for large vocabulary speech recognition, context-dependent (CD) modeling is essential for realizing both improved recognition performance and rapid search. However, sparse data problem caused by huge number of CD models usually leads the estimated models unreliable. To cope with that, two major context-clustering methods, datadriven and rule-based, have been investigate...

Abstract: Purpose: The purpose of this research paper is to develop a prediction model for Parkinson’s disease. There are many symptoms that lead to Parkinson’s disease such ageenvironmentalfactor, trembling in the legs, arms, hands, impaired speech articulation and production difficulties. In this research paper speech articulation of Parkinson’s disease affected people is considered for model...

The rapid development of college information construction has promoted the processing and analysis a large number data in system. Decision tree algorithm is often used field financial analysis, but it bias selection attributes. Aiming at defects decision attribute selection, ID3 selected for weighted improvement, optimized based on Synthetic Minority Oversampling Technique (SMOTE) Bagging to ba...

Transforming growth factors beta (TGF-betas) inhibit growth of epithelial cells and induce differentiation changes, such as epithelial-mesenchymal transition (EMT). On the other hand, bone morphogenetic proteins (BMPs) weakly affect epithelial cell growth and do not induce EMT. Smad4 transmits signals from both TGF-beta and BMP pathways. Stimulation of Smad4-deficient epithelial cells with TGF-...

Id1 and Id3 genes are required for vascularization, growth, and metastasis of xenograft tumors. In Id-deficient mice, tumor transplantation and proangiogenic factors fail to mobilize and recruit circulating endothelial precursor cells (CEPs) and hematopoietic cells, leading to defective tumor angiogenesis in various models. To investigate the requirement of Id genes and bone marrow incorporatio...

Angiogenesis plays a pivotal role in the aggressive proliferation of synovial cells in rheumatoid arthritis. We have previously reported the overexpression of inhibitor of DNA binding/differentiation (Id) in the endothelial cells within the synovial tissues of rheumatoid arthritis. In this study, we investigated the role of Id in inflammation and angiogenesis in an in vitro model using HUVECs. ...

Resumen. La apendicitis aguda es una enfermedad de dif́ıcil diagnostico en ancianos y niños, en la mayoŕıa de los casos se presenta un dolor en el ombligo que aumenta conforme al tiempo y se dirige hacia el cuadrante inferior derecho. Por su diversidad sintomatológica, existen propuestas de diagnóstico que se limitan a unos cuantos śıntomas, signos y laboratorios. La apendicitis aguda por ser un...

RATIONALE Angiotensin II (Ang II) has diverse effects on smooth muscle cells (SMCs). The diversity of effects may relate to the regional location of this cell type. OBJECTIVE The aim of this study was to define whether Ang II exerted divergent effects on smooth muscle cells in the aorta and determine the role of blood pressure and specific oxidant mechanisms. METHODS AND RESULTS Ang II (100...

Decision tree is an effective classification approach in data mining and machine learning. In applications, test costs and misclassification costs should be considered while inducing decision trees. Recently, some cost-sensitive learning algorithms based on ID3 such as CS-ID3, IDX, λ-ID3 have been proposed to deal with the issue. These algorithms deal with only symbolic data. In this paper, we ...