نتایج جستجو برای: idiopathic parkinson disease
تعداد نتایج: 1538852 فیلتر نتایج به سال:
OBJECTIVE To investigate whether serum vitamin D level predicts the risk of Parkinson disease. DESIGN Cohort study. SETTING The study was based on the Mini-Finland Health Survey, which was conducted from 1978 to 1980, with Parkinson disease occurrence follow-up through the end of 2007. During the 29-year follow-up period, 50 incident Parkinson disease cases occurred. Serum 25-hydroxyvitamin...
BACKGROUND Sex differences in Parkinson disease clinical features have been reported, but few studies have examined sex influences on use of dopaminergic medication in early Parkinson disease. The objective of this study was to test if there are differences in the type of dopaminergic medication used and levodopa equivalent daily dose between men and women with early Parkinson disease enrolled ...
Background Hydrogen Sulfide (H2S), a novel endogenous gasotransmitter, plays an important role in neuromodulation and memory performance and also protects neurons against neurotoxin-induced neurodegeneration. Objective This study aimed to investigate the potential neuroprotective effects of Sodium Hydrosulfide (NaHS), on motor learning in a unilateral 6-Hydroxydopamine (6-OHDA) rat model of Pa...
BACKGROUND Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Parkinson's disease (PD). The International LRRK2 Consortium was established to answer three key clinical questions: can LRRK2-associated PD be distinguished from idiopathic PD; which mutations in LRRK2 are pathogenic; and what is the age-specific cumulative risk of PD for individuals who inherit o...
PURPOSE To determine whether the proton spectra from patients with clinically diagnosed Parkinson disease differ from the spectra of age-matched healthy subjects with respect to the major cerebral metabolite resonances as well as lactate. METHODS Fourteen patients with Parkinson disease (38 to 81 years of age) and 13 healthy control subjects (37 to 81 years of age) were studied using image-gu...
conclusions since the severity of the behavioral symptoms in the 6-ohda-induced model of parkinson disease reflects the degree of the lesion in substantia nigra (sn) dopaminergic neurons, it is suggested that using the combination had neuroprotective effects. the obtained data suggest a synergistic neuroprotective and antiparkinsonian effect for flu, glib and b com. at least, a part of this eff...
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