OBJECTIVE Alcoholics who are at risk for infectious disease show profound disturbances of sleep along with decrements of cellular immunity. This study examined the relationships between sleep, nocturnal expression of immunoregulatory cytokines, and natural killer (NK) cell activity in alcoholic patients as compared with control subjects. METHODS Alcoholic patients (N = 24) and comparison cont...

Modification of recombinant human interleukin-2 (IL-2) with polyethylene glycol (PEG-IL-2) decreases clearance and might favor absorption into the lymphatics, due to its increased molecular weight. In the present study, we compared the plasma and lymph concentrations of IL-2 and PEG-IL-2 in Yorkshire pigs. The IL-2 regimens were i.v. bolus (0.1-1.6 x 10(6) I.U., MIU/kg), 15-min i.v. infusion (0...

Bacteria are known both to exhibit anticytokine activity (ACA), i.e., secrete extracellular compounds which inactivate / neutralize various cytokines, and produce cytokine-like substances (CPV) released the culture medium. At same time, ability of Candida such has not been previously studied. The purpose our study was determine presence ACA CPV in strains isolated from reproductive tract appare...

background: multiple sclerosis (ms) is known as a progressive central nervous system inflammatory disease. certain factors, such as interleukins, inflammatory cells, and oxidative stress are supposed to involve in ms etiology. because of the important role of oxidative stress, antioxidant therapy for ms has received more attention. although coenzyme q10 (coq10) acts as an antioxidant, there is ...

background and aims . periodontitis is a multifactorial disease. varieties of microbial and environmental, as well as genetic factors are reported to influence risk for periodontitis. the present study sought to test the putative involvement of il-10 and il-18 gene polymorphism in pre-disposition to periodontitis in patients had exposure to chemical agent as a risk factor for periodontitis deve...

background: to investigate the expression of tnf-α, il-6, il-10 in the plasma of patients with lung cancer who received radiation therapy (rt), and to analyze the correlation between these cytokines and radiation pneumonitis (rp). materials and methods: patients with lung cancer who received 3d-crt in our hospital were prospectively evaluated. circulating cytokine levels were measured with elis...

Ischemia induces both hypoxia and inflammation that trigger angiogenesis. The inflammatory reaction is modulated by production of anti-inflammatory cytokines. This study examined the potential role of a major anti-inflammatory cytokine, interleukin (IL)-10, on angiogenesis in a model of surgically induced hindlimb ischemia. Ischemia was produced by artery femoral occlusion in both C57BL/6J IL-1...

This study aimed to evaluate whether the interleukin-6 (IL-6) and interleukin-10 (IL-10) ratio (IL-6/IL-10) can be used as a prognostic marker of recurrence following bacillus Calmette-Guérin (BCG) therapy in patients with high-risk non-muscle invasive bladder cancer (NMIBC). One hundred and twenty-one consecutive urological patients (72 affected by high-risk NMIBC and 49 controls) were selecte...