نتایج جستجو برای: il28b polymorphisms

تعداد نتایج: 67261  

2014
Simone Regina Souza da Silva Conde Julius Caesar Mendes Soares Monteiro Bruna Tereza Silva dos Santos Nathália Karla Fonseca Filgueiras Pedro Alves de Almeida Lins Felipe Bonfim Freitas Ednelza da Silva Graça Sâmia Demachki Marialva Tereza Ferreira de Araújo Ricardo Ishak Antonio Carlos Rosário Vallinoto

AIM The aim of this study was to characterize the genetic profile of patients with chronic hepatitis C virus (HCV) infection relative to polymorphisms rs12979860 and rs8099917 in gene IL28B and the association of those polymorphisms with the response to treatment with pegylated interferon and ribavirin, performed at a reference center in Brazilian Amazonia. METHODS A total of 75 individuals w...

Journal: :AIDS 2011
Norma I Rallón Vincent Soriano Susanna Naggie Clara Restrepo David Goldstein Eugenia Vispo John McHutchison José M Benito

BACKGROUND A single nucleotide polymorphism (SNP) upstream of the IL28B gene (rs12979860) predicts sustained virological response (SVR) to peginterferon-ribavirin therapy in chronic hepatitis C patients. There is scarce information regarding the influence of this IL28B SNP on early viral kinetics during therapy, particularly in patients coinfected with HIV, in whom treatment response is lower t...

Journal: :Antiviral research 2012
Wei Li Yanli Zeng Junjie Wang Bin Zhou Jian Zhang Hao Zhang Jingtao Li Yingsong Wu Rifat Hamoudi Yuanping Zhou

Recent studies showed that two single nucleotide polymorphisms (SNPs) (rs12979860 and rs8099917) near the gene IL28B coding for IFNλ3 were associated with the antiviral treatment response of the combination therapy of pegIFN plus RBV. We established the use of tetra-primer amplification refractory mutation system polymerase chain reaction (ARMS-PCR) for detecting IL28B rs8099917 genotype (T>G) ...

Journal: :Intervirology 2014
Ela Akay Mauli Patel Tim Conibear Turren Chaggar Tanzina Haque

OBJECTIVES Single-nucleotide polymorphisms (SNPs) near the interleukin (IL) 28B gene encoding a type III interferon (IFN-λ) are the most important genetic predictors of treatment response to hepatitis C virus (HCV). This retrospective study was undertaken to determine any association between IL28B SNPs and the development of viraemia in Epstein-Barr virus (EBV)-driven acute infectious mononucle...

2015
Frédégonde About Tiphaine Oudot-Mellakh Jonathan Niay Pascaline Rabiéga Vincent Pedergnana Darragh Duffy Philippe Sultanik Carole Cagnot Fabrice Carrat Patrick Marcellin Fabien Zoulim Dominique Larrey Christophe Hézode Hélène Fontaine Jean-Pierre Bronowicki Stanislas Pol Matthew L. Albert Ioannis Theodorou Aurélie Cobat Laurent Abel Chen-Hua Liu

BACKGROUND Human genetic factors influence the outcome of pegylated interferon and ribavirin hepatitis C therapy. We explored the role of IL28B, APOH and ITPA SNPs on the outcomes of triple therapy including telaprevir or boceprevir in patients with compensated cirrhosis chronically infected with HCV-1. PATIENTS AND METHODS A total of 256 HCV-1 Caucasian treatment-experienced patients with co...

2017
Dzmitry Danilau Dzmitry Litvinchuk Nikita Solovey Olga Krasko Igor Karpov

AIM OF THE STUDY To evaluate the role of potential genetic predictors -308G/A TNF-α and -403G/A CCL5 in treatment for HCV 1 genotype. MATERIAL AND METHODS Treatment results of 130 patients with chronic hepatitis C 1 genotype according to different genotypes of IL28B, CCL5, and TNF-α were analysed using multiple logistic regression. RESULTS IL28B genotypes CC/CT/TT were found in 27 (20.8%), ...

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